Contingency Management to Promote Smoking Cessation

NCT06456242 | Completed DMC

• 1 other identifier: DA055779
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Many hospitals and outpatient clinics often refer people who smoke to quitlines and provide prescriptions for smoking cessation medications, but patients rarely fully engage in counseling or use their cessation medications. This is a single-arm, open-label pilot study to provide feasibility metrics for a text-based contingency management (CM) intervention to increase engagement in smoking cessation treatment. All participants (N=20) will be referred to a state quitline and will receive a prescription for medication plus 12 weeks of a text-based CM intervention to increase engagement in quitline calls and varenicline utilization. The engagement of participants in quitline counseling will be tracked for 6 weeks and medication utilization for 12 weeks post-enrollment. The investigators will use mixed-methods to collect implementation and acceptability data to inform changes to the text-based contingency management (CM) intervention.

Conditions

Smoking Cessation

Outcome Measures

Primary Outcomes (2)

• Proportion of quitline calls completed

  Completion of the five quitline calls over 6 weeks of treatment according to Kansas quitline reports

  Week 6

• Proportion of varenicline pills taken

  Varenicline intake over 12 weeks of treatment according to the smart pill dispenser counting

  Week 12

Secondary Outcomes (4)

• Proportion of patients adherent to varenicline

  Week 3

• Proportion of self-reported varenicline pills taken

  Week 3

• Proportion of patients with biochemically verified smoking abstinence

  Week 12

• Proportion of patients with self-reported smoking abstinence

  Week 12

Study Arms (1)

MedCM plus CounsCM

EXPERIMENTAL

Mobile Contingency Management for counseling attendance and medication intake

Behavioral: CounsCM+MedCM (Health Rewards)

Interventions

CounsCM+MedCM (Health Rewards) BEHAVIORAL

Small financial incentives for completing quitline calls (CounsCM) plus small financial incentives for taking varenicline (MedCM).

MedCM plus CounsCM

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Smoked in the past 30 days
• Smoke at least 1 cigarette per day when they smoke
• ≥ 18 years old
• Kansas resident
• Speak/read English
• Access to a mobile phone
• Mobile phone receives text messages
• No varenicline contraindications (no acute renal impairment)
• Insurance coverage for varenicline
• Have no significant co-morbidity (i.e., life-threatening illness, communication barriers or altered mental status)
• Cognitively able to participate
• Physically able to participate
• Not pregnant/breastfeeding

You may not qualify if:

• Medically ineligible for varenicline
• Patient on smoking cessation medication within 2 weeks of admission date
• Patient already talked to quitline in the past 2 weeks.
• Patients participating in other quit smoking program or research study

Sponsors & Collaborators

• University of Oklahoma: collaborator
• National Institute on Drug Abuse (NIDA): collaborator
• University of Kansas Medical Center: lead

Study Sites (1)

University of Kansas Medical Center

Kansas City, Kansas, 66103, United States

Location

MeSH Terms

Conditions

Smoking Cessation

Condition Hierarchy (Ancestors)

Health Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 4, 2024
• First Posted: June 13, 2024
• Study Start: September 20, 2024
• Primary Completion: January 30, 2026
• Study Completion: January 30, 2026
• Last Updated: May 5, 2026

Record last verified: 2026-04

Locations

US (1)