NCT06452264

Brief Summary

This study seeks to conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 5, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 11, 2024

Completed
8 days until next milestone

Study Start

First participant enrolled

June 19, 2024

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2024

Completed
Last Updated

June 21, 2024

Status Verified

June 1, 2024

Enrollment Period

5 months

First QC Date

June 5, 2024

Last Update Submit

June 19, 2024

Conditions

Keywords

processing speed

Outcome Measures

Primary Outcomes (3)

  • Useful Field of View (UFOV)

    computerized processing speed task

    baseline to immediate post-treatment (week 13) and long-term follow-up (week 25)

  • Letter and Pattern Comparison (LPC)

    processing speed task, using both letter and pattern strings

    baseline to immediate post-treatment (week 13) and long-term follow-up (week 25)

  • Symbol Digit Modalities Test (SDMT)

    processing speed task, matching numbers to symbols using a key

    baseline to immediate post-treatment (week 13) and long-term follow-up (week 25)

Secondary Outcomes (1)

  • Spinal Cord Injury Quality of Life scales (SCI-QOL)

    baseline to immediate post-treatment (week 13) and long-term follow-up (week 25)

Study Arms (2)

Experimental

EXPERIMENTAL

pre-specified computer tasks using an Internet-based cognitive training portal, to be completed 3x per week for 60 minutes each session for 12 weeks total

Behavioral: game-like computerized activities

Placebo Control

PLACEBO COMPARATOR

pre-specified computer tasks using an Internet-based cognitive training portal, to be completed 3x per week for 60 minutes each session for 12 weeks total

Behavioral: game-like computerized activities

Interventions

game-like computerized activities

Experimental

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years old
  • recent traumatic SCI (approximately 6 months post-injury)

You may not qualify if:

  • no other significant neurological, psychiatric or substance use history
  • no significantly impairing visual disturbance

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kessler Foundation

East Hanover, New Jersey, 07936, United States

RECRUITING

MeSH Terms

Conditions

Spinal Cord InjuriesCognitive Dysfunction

Condition Hierarchy (Ancestors)

Spinal Cord DiseasesCentral Nervous System DiseasesNervous System DiseasesTrauma, Nervous SystemWounds and InjuriesCognition DisordersNeurocognitive DisordersMental Disorders

Study Officials

  • Erica Weber, PhD

    Kessler Foundation

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 5, 2024

First Posted

June 11, 2024

Study Start

June 19, 2024

Primary Completion

November 30, 2024

Study Completion

November 30, 2024

Last Updated

June 21, 2024

Record last verified: 2024-06

Data Sharing

IPD Sharing
Will not share

Locations