Acute Effects of HIIT vs. MICT on HRV

NCT06437145 | Recruiting

• 1 other identifier: UKCLRehab2024/1
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Heart rate variability (HRV) is impaired in patients after myocardial infarction. Most studies so far have proved chronic beneficial effects of different types of exercise on HRV parameters. Data on acute effects of different types of exercise training (e.g. high intensity interval training \[HIIT\] and moderate intensity continuous training \[MICT\]) is scarce. Patients in the study will perform both HIIT and MICT in a random order and in-between break of at least 48 hours. A 5-minute high resolution ECG recording will be performed before and immediately after both HIIT and MICT.

Conditions

Myocardial Infarction

Keywords

exercise training; high intensity interval training; moderate intensity continuous training; heart rate variability; myocardial infarction

Outcome Measures

Primary Outcomes (1)

• HF parameter

  High frequency domain of the HRV

  5-minutes high resolution ECG recording before and after an exercise session

Secondary Outcomes (4)

• LF parameter

  5-minutes high resolution ECG recording before and after an exercise session

• SDNN

  5-minutes high resolution ECG recording before and after an exercise session

• RMSSD

  5-minutes high resolution ECG recording before and after an exercise session

• pNN50

  5-minutes high resolution ECG recording before and after an exercise session

Other Outcomes (1)

• Non-linear methods

  5-minutes high resolution ECG recording before and after an exercise session

Study Arms (2)

High intensity interval training (HIIT)

ACTIVE COMPARATOR

The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak.

Other: Type of Exercise

Moderate intensity continuous training (MICT)

ACTIVE COMPARATOR

The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.

Other: Type of Exercise

Interventions

Type of Exercise OTHER

The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.

High intensity interval training (HIIT); Moderate intensity continuous training (MICT)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• myocardial infarction in last 120 days
• sinus rhythm

You may not qualify if:

• contraindications for exercise training
• uncontrolled dysrhythmias
• Heart Failure NYHA IV stage
• cognitive impairment
• pregnancy

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Study Sites (1)

University Medical Centre Ljubljana

Ljubljana, 1000, Slovenia

RECRUITING

Related Publications (3)

• Routledge FS, Campbell TS, McFetridge-Durdle JA, Bacon SL. Improvements in heart rate variability with exercise therapy. Can J Cardiol. 2010 Jun-Jul;26(6):303-12. doi: 10.1016/s0828-282x(10)70395-0.

  PMID: 20548976 BACKGROUND

• El-Malahi O, Mohajeri D, Mincu R, Bauerle A, Rothenaicher K, Knuschke R, Rammos C, Rassaf T, Lortz J. Beneficial impacts of physical activity on heart rate variability: A systematic review and meta-analysis. PLoS One. 2024 Apr 5;19(4):e0299793. doi: 10.1371/journal.pone.0299793. eCollection 2024.

  PMID: 38578755 BACKGROUND

• Grassler B, Thielmann B, Bockelmann I, Hokelmann A. Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act. 2021 Nov 17;18(1):24. doi: 10.1186/s11556-021-00278-6.

  PMID: 34789148 BACKGROUND

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Marko Novaković, MD, PhD

  University Medical Centre Ljubljana

  STUDY CHAIR

Central Study Contacts

Marko Novaković, MD, PhD

CONTACT

0038615228032; marko.novakovic@kclj.si

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: HRV parameters analysis will be blinded regarding the exercise training modality.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Model Details: Each patient will have a bout of HIIT during one session and a bout of MICT during another session performed in a random order.

Study Record Dates

• First Submitted: April 16, 2024
• First Posted: May 31, 2024
• Study Start: February 15, 2024
• Primary Completion: June 1, 2024
• Study Completion: June 15, 2024
• Last Updated: May 31, 2024

Record last verified: 2024-05

Locations

SL (1)