Recurrent Campylobacter Bacteraemia in Immunocompromised Patients
CABARET
CABARET
Sponsor study identifier
observational
30
1 country
1
Study Start
June 1, 2024
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Primary Completion
May 1, 2025
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Study Completion
May 1, 2026
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Some rare cases of recurrent Campylobacter bacteraemia (RCB) exist with relapses months to years after an effective treatment and a negativation of all bacterial samples. As of today, only around 20 cases have been described in the international literature for the last 30 years. The cases are likely highly underreported. No study describes those recurrent Campylobacter bacteraemias at the scale of a country. The aim of this multicentre, nationwide, retrospective study is to describe their precise epidemiology in France for the last 25 years, the immune profile of the patients, the specificities of the bacteria involved, the treatments received and the evolution of these infections. The perspective is to propose a standardization of the medical care of those patients mainly by describing the effective treatments and the explorations of the immune system which should be considered.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 1, 2026
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 14, 2024
Actual (reported)May 29, 2024
Actual (reported)June 1, 2024
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May 1, 2025
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May 1, 2026
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Description of the characteristics of the patients presenting with recurrent Campylobacter bacteraemia
-demographic characteristics
Baseline
Description of the characteristics of the patients presenting with recurrent Campylobacter bacteraemia
-characteristics of immunodeficiency: diagnosis, immunoglobulin dosage, white cells count, polyvalent Ig replacement therapy
Baseline
Description of the characteristics of the patients presenting with recurrent Campylobacter bacteraemia
-chronic inflammatory bowel disease \[IBD\]
Baseline
Description of the characteristics of the patients presenting with recurrent Campylobacter bacteraemia
-characteristics of bacteraemia: clinical presentation, bacteria (species, antimicrobial susceptibility), secondary localizations, evolution, treatment modalities (antibiotics and immunother
Baseline
Patients presenting at least two distinct episodes of Campylobacter bacteraemia separated by minimum 60 days and an immunodeficiency (innate or acquired) and followed by a French hospital
Variables: characteristics of the patients (demographic characteristics; characteristics of immunodeficiency: diagnosis, immunoglobulin dosage, white cells count etc.; chronic inflammatory bowel disease \[IBD\]), the bacteria (species, antimicrobial susceptibility) and the infection (clinical presentation, evolution, treatment received)
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French hospitals
Infectious diseases department, Hospital de la Croix Rousse,
Lyon, 69004, France
First Submitted
May 14, 2024
First Posted
May 29, 2024
Study Start
June 1, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
May 1, 2025
Estimated (date passed)Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
May 1, 2026
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Last Updated
May 29, 2024
Record last verified: 2024-05
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