A SAD Study of ZT002 Injection in Healthy Participants

NCT06423872 | Completed Phase 1

• 1 other identifier: BJQLZT002002
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

This study will comprise a randomized, parallel assignment, double blind, placebo controlled, single and multiple ascending dose, safety, tolerability and pharmacokinetic study of ZT002 in healthy participants.

Conditions

Type 2 Diabetes Mellitus

Outcome Measures

Primary Outcomes (2)

• Safety and tolerability of a single escalation dose of ZT002 through the incidence and severity of treatment emergent adverse events in SAD Cohorts. Number of participants with treatment-emergent adverse events

  Coded by the most updated version of the Medical Dictionary for Regulatory Activities (MedDRA).

  Up to 50 days

• Safety and tolerability of a single escalation dose of ZT002 through the incidence severity of serious adverse events in SAD Cohorts. Number of participants with serious adverse events.

  Coded by the most updated version of the Medical Dictionary for Regulatory Activities (MedDRA).

  Up to 50 days

Secondary Outcomes (3)

• The Pharmacokinetics (PK) profile of a single escalation dose of ZT002 in healthy participants in SAD Cohorts.

  Up to 50 days

• The Pharmacokinetics (PK) profile of a single escalation dose of ZT002 in healthy participants in SAD Cohorts.

  Up to 50 days

• The Pharmacokinetics (PK) profile of a single escalation dose of ZT002 in healthy participants in SAD cohorts.

  Up to 50 days

Study Arms (2)

ZT002

EXPERIMENTAL

Participants will be randomized to receive ZT002 injection or Placebo in 1 of 6 dose cohorts.

Drug: ZT002

Placebo

PLACEBO COMPARATOR

Participants will be randomized to receive ZT002 injection or Placebo in 1 of 6 dose cohorts.

Other: Placebo

Interventions

ZT002 DRUG

Participants will receive a single subcutaneous (SC) ZT002 injection.

ZT002

Placebo OTHER

Participants will receive same volume as of the study drug.

Placebo

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Fully understand the purpose, nature, methods, and potential adverse reactions of the experiment, voluntarily participate as a participant, comply with the requirements of this study, and sign an informed consent form.
• Healthy adults, age 18\~45 years, both inclusive, at time of informed consent.
• Body Mass Index (BMI) between 19～27.0 kg/m2 both included. Male weight\>55.0kg, famale weight\>50.0kg.
• In good health, determined by no clinically significant findings from medical history, physical examination, vital signs measurements, anterior and lateral chest X-ray,12-lead ECG, and clinical laboratory evaluations(blood routine, blood biochemistry, coagulation function, and urine routine)at screening and before administration of study drug, as assessed by the Investigator.
• Female participants are required to abstain or use two effective contraceptive methods simultaneously from 1 month before screening to 6 months after the last dose. Male participants are required to abstain or use two effective contraceptive methods simultaneously from the first dose to 6 months after the last dose: male participants are required to undergo surgical sterilization (such as vas deferens ligation) or use condoms correctly, or their spouse is required to use hormonal contraceptives approved by the National Medical Products Administration (such as contraceptive pills, patches, implantable or injectable preparations) or intrauterine devices (IUDs) or undergo surgical sterilization; Female subjects may undergo surgical sterilization (such as tubal ligation) or intrauterine devices (IUDs), or their spouses may use condoms correctly or undergo surgical sterilization. After the trial, female subjects may also use hormone contraceptives approved by the National Medical Products Administration (such as contraceptive pills, patches, implantable or injectable preparations).

You may not qualify if:

• History of drug allergy or allergic related diseases (allergic rhinitis, asthma, urticaria, eczema, etc.)，allergic to experimental drugs and excipients or GLP-1 class drugs.
• Significant history or clinical manifestation of any neurological, cardiovascular, hematological, hepatic, renal, gastrointestinal, respiratory, metabolic, endocrine, immune or skeletal, as determined by the Investigator.
• Family or personal history of medullary thyroid carcinoma (MTC).
• Medical history of multiple endocrine neoplasia type 2(MEN2).
• History of acute or chronic pancreatitis.
• History of hypoglycemia.
• Calcitonin equal or above 50 ng/L at screening.
• The content of amylase or lipase during the screening period is higher than the upper limit of normal values and has clinical significance.
• Screening period HbAlc (glycated hemoglobin) ≥ 6.5%.
• According to the Fridericias formula，QTcF ≥ 450 ms for subjects in 12-lead ECG examination during screening or baseline period.
• History of drug abuse within the previous year of screening or positive results from drug abuse screening (urine screening).
• Have smoked ≥5 cigarettes per day in the past 3 month prior to Screening or unable to refrain from smoking during the study.
• Screening for subjects who have consumed more than 14 units of alcohol per week within the first 3 months (1 unit of alcohol=360 mL of beer or 45 mL of 40% alcohol or 150 mL of wine), or who have taken alcoholic products within 48 hours before administration, or who cannot abstain from alcohol during the trial period.
• Positive test for hepatitis B surface antigen (HBsAg)，hepatitis C antibody (HCV-Ab), human immunodeficiency virus (HIV-Ab) antibody, treponema pallidum(TP-Ab) antibody at screening.
• Screening for subjects who have participated in other clinical trials and received drug therapy or medical device intervention within the first 3 months.

Sponsors & Collaborators

• Beijing QL Biopharmaceutical Co.,Ltd: lead
• Beijing Hospital: collaborator

Study Sites (1)

Beijing Hospital

Beijing, Beijing Municipality, China

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Aixin Shi, Master

  No.1 Dahua Road, Dongdan, Dongcheng District, Beijing

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 16, 2024
• First Posted: May 21, 2024
• Study Start: June 19, 2023
• Primary Completion: October 20, 2023
• Study Completion: December 8, 2023
• Last Updated: May 21, 2024

Record last verified: 2024-05

Locations

CN (1)