NCT06423274

Brief Summary

This study plans to compare the accuracy of artificial intelligence (AI)-assisted fundus images with other ophthalmic devices such as optical coherence tomography (OCT) and fundus fluorescence angiography (FFA) in the diagnosis of diabetic retinopathy and diabetic macular edema.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2024

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 9, 2024

Completed
12 days until next milestone

First Posted

Study publicly available on registry

May 21, 2024

Completed
2 months until next milestone

Study Start

First participant enrolled

July 10, 2024

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2025

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
Last Updated

July 9, 2024

Status Verified

July 1, 2024

Enrollment Period

1.1 years

First QC Date

May 9, 2024

Last Update Submit

July 4, 2024

Conditions

Keywords

diabetic retinopathydiabetic macular edemaartificial intelligence

Outcome Measures

Primary Outcomes (1)

  • The accuracy

    Detection of DR accuracy using fundus photography, optical coherence tomography, and fundus fluorescence angiography

    Baseline-Month 12

Secondary Outcomes (1)

  • The accuracy

    Baseline-Month 12

Study Arms (3)

artificial intelligence-assisted fundus photography

Artificial intelligence-assisted fundus photography in patients with diabetic retinopathy

Diagnostic Test: fundus photography

optical coherence tomography

optical coherence tomography in patients with diabetic retinopathy

Diagnostic Test: optical coherence tomography

fundus fluorescence angiography

fundus fluorescence angiography in patients with diabetic retinopathy

Diagnostic Test: fundus fluorescence angiography

Interventions

fundus photographyDIAGNOSTIC_TEST

using artificial intelligence to identify diabetic retinopathy using fundus photography

artificial intelligence-assisted fundus photography

detect diabetic retinopathy and diabetic macular edema by optical coherence tomography

optical coherence tomography

detect diabetic retinopathy by fundus fluorescence angiography

fundus fluorescence angiography

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

It is planned to include 1,000 participants in the study, all of whom will undergo fundus photography, 500 additional patients will undergo fundus fluorescence angiography, and 500 additional patients will undergo optical coherence tomography. All participants met inclusion and exclusion criteria.

You may qualify if:

  • Diagnostic for diabetes: Type 1 diabetes of a lest 5 years of evolution; or Type 2 diabetes;
  • Obtaining informed consent;
  • Patient age 18 or above.

You may not qualify if:

  • Patients under 18 years of age;
  • Failure to Obtain informed consent;
  • Presence of other retinal diseases;
  • A patient who has already undergone the treatment.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310000, China

Location

MeSH Terms

Conditions

Diabetic Retinopathy

Interventions

Fluorescein AngiographyTomography, Optical Coherence

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System Diseases

Intervention Hierarchy (Ancestors)

AngiographyDiagnostic Techniques, CardiovascularDiagnostic Techniques and ProceduresDiagnosisDiagnostic Techniques, OphthalmologicalTomography, OpticalOptical ImagingDiagnostic ImagingTomographyInvestigative Techniques

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director

Study Record Dates

First Submitted

May 9, 2024

First Posted

May 21, 2024

Study Start

July 10, 2024

Primary Completion

September 1, 2025

Study Completion

December 31, 2025

Last Updated

July 9, 2024

Record last verified: 2024-07

Data Sharing

IPD Sharing
Will not share

Locations