NCT06422897

Brief Summary

Assessment of healing of thin and perforated cornea after surgical treatment by anterior segment optical coherence tomography

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
13

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Apr 2024

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 15, 2024

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

May 15, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 21, 2024

Completed
9 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2024

Completed
6 days until next milestone

Study Completion

Last participant's last visit for all outcomes

June 5, 2024

Completed
Last Updated

July 23, 2024

Status Verified

July 1, 2024

Enrollment Period

2 months

First QC Date

May 15, 2024

Last Update Submit

July 21, 2024

Conditions

Corneal Perforation

Outcome Measures

Primary Outcomes (1)

  • Depth of corneal healing measured by optical coherence tomography

    complete corneal healing by anterior segment optical coherence tomography

    1 month

Study Arms (1)

cases after surgical management

cases are assessed by Anterior segment optical coherence tomography 1 month after surgical managemnt

Other: anterior segment optical coherence tomography

Interventions

anterior segment optical coherence tomographyOTHER

surgically treated corneal perforation by amniotic membrane graft and platelet rich plasma clot is assessed by anterior segment optical coherence tomography 1 month postoperative

cases after surgical management

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients from both sexes was thin cornea or small corneal perforation surgically treated by amniotic membrane graft and platelet rich plasma clot

You may qualify if:

  • thin cornea about to perforate
  • small corneal perforation

You may not qualify if:

  • active infection

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Medicine

Minya, Egypt

Location

Related Publications (1)

  • Abdelghany AA, Bahrawy ME, Alio JL. Combined Platelet Rich Plasma and Amniotic membrane in the treatment of Perforated Corneal Ulcers. Eur J Ophthalmol. 2022 Jul;32(4):2148-2152. doi: 10.1177/11206721211049100. Epub 2021 Oct 8.

    PMID: 34623187RESULT

MeSH Terms

Conditions

Corneal Perforation

Condition Hierarchy (Ancestors)

Corneal InjuriesEye InjuriesFacial InjuriesCraniocerebral TraumaTrauma, Nervous SystemNervous System DiseasesCorneal DiseasesEye DiseasesWounds and Injuries

Study Officials

  • Ahmed A Abdelghany, professor

    professor

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate professor

Study Record Dates

First Submitted

May 15, 2024

First Posted

May 21, 2024

Study Start

April 15, 2024

Primary Completion

May 30, 2024

Study Completion

June 5, 2024

Last Updated

July 23, 2024

Record last verified: 2024-07

Locations

EG(1)