The Semaglutide Study

NCT06420739 | Active Not Recruiting

• 1 other identifier: 23-5873
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The primary goal of this study is to evaluate the incidence of "full stomach" in fasting elective surgical patients on Semaglutide medication. The other goals are to study the impact of the time interval since the last dose of the medication on the incidence of full stomach and to develop evidence-based recommendations for the perioperative management of these patients.

Conditions

Fasting

Keywords

Gastric Ultrasound; Fasting; Semaglutide; Elective surgery

Outcome Measures

Primary Outcomes (1)

• Incidence of full stomach.

  Frequency of full stomach in patients taking semaglutide and fasting before surgery. Analysis of the primary outcome will be based on a chi-square analysis.

  Pre-Surgical fasting duration per guideline

Secondary Outcomes (2)

• Any changes in anesthetic management from the a priori plan following the result of the gastric ultrasound examination.

  Pre-operative anesthesia management plan

• Impact of age, sex and the time since the last dose of Semaglutide, on the incidence of "full stomach".

  Pre-Surgical fasting duration per guideline

Interventions

Gastric Ultrasound DIAGNOSTIC_TEST

Bedside Gastric Ultrasound to determine the volume and nature of gastric content in patients before their surgery.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A cohort of 100 patients undergoing elective surgery while under treatment with Semaglutide for either diabetes or for losing weight.

You may qualify if:

• Patients scheduled for elective surgery at Toronto Western Hospital
• Aged ≥ 18 years of age
• American Society of Anaesthesia physical status classification I to III
• Patients being treated with Semaglutide for at least 1 month

You may not qualify if:

• Current pregnancy evidenced by positive urinary pregnancy test
• Previous surgery of the upper gastrointestinal tract

Sponsors & Collaborators

• University Health Network, Toronto: lead

Study Sites (1)

Toronto Western Hospital

Toronto, Ontario, M5T 2S8, Canada

Location

MeSH Terms

Conditions

Fasting

Condition Hierarchy (Ancestors)

Feeding Behavior; Behavior

Study Officials

• Anahi Perlas

  Investigator-Sponsor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 10, 2024
• First Posted: May 20, 2024
• Study Start: March 25, 2024
• Primary Completion: November 30, 2025
• Study Completion: March 31, 2026
• Last Updated: November 20, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)