NCT06417541|Recruiting
Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters
PHOTO CAT
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PHOTO CAT
Sponsor study identifier
observational
75
1 country
1
Study Start
January 16, 2025
Actual (reported)Primary Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were designed. In sub-study 1, deceased patients with CVC who are referred for clinical autopsy are included. Before the autopsy, the deceased will be examined with a photon-counting computed tomography (CT) scan and the results will be compared. In sub-study 2, living patients with CVC who are referred for various CT scans without contrast, are included. After informed consent, the patient will be examined with the photon-counting CT, whose reliability has been validated in Part 1 and the incidence of subclinical CVC-related thrombosis will be reported.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 11, 2024
Actual (reported)May 16, 2024
Actual (reported)January 16, 2025
Actual (reported)June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The incidence of venous thrombosis related to a central venous catheter in diseased patients
Venous thrombosis related to a central venous catheter detected at autopsy
At autopsy
The performance of the photon counting CT on diseased patients
The performance of the photon counting CT will be evaluated by comparing the findings from the CT with the findings from the autopsy
After death. The CT scan and the autopsy will be performed within 1 week after death
The incidence of venous thrombosis related to a central venous catheter in living patients
The incidence of venous thrombosis related to a central venous catheter in living patients detected with a photon counting CT
At CT scan
The performance of ultrasound compared to the photon counting CT
The performance of ultrasound compared to the photon counting CT in detecting enous thrombosis related to central venous catheters
Ultrasound will be performed ±24 hours from the CT
Sub study 1, Diseased patients with an indwelling central venous catheter
Living patients with an indwelling central venous catheter who are referred to a CT-scan without intravenous contrast
Photon counting CT is performed and the results are compared to the results of the autopsy
Patients will be investigated using a photon counting CT. Prior to the investigation patients will be investigated with ultrasound. The results from the two modalities will be compared
Substudy 1: Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy Substudy 2: Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast
Intensive and Perioperative Care. Skåne University Hospital. Lund
Lund, Skåne County, 22185, Sweden
Forauer AR, Theoharis C. Histologic changes in the human vein wall adjacent to indwelling central venous catheters. J Vasc Interv Radiol. 2003 Sep;14(9 Pt 1):1163-8. doi: 10.1097/01.rvi.0000086531.86489.4c.
Wichmann D, Heinemann A, Zahler S, Vogel H, Hopker W, Puschel K, Kluge S. Prospective study of device-related complications in intensive care unit detected by virtual autopsy. Br J Anaesth. 2018 Jun;120(6):1229-1236. doi: 10.1016/j.bja.2018.02.031. Epub 2018 Apr 4.
Thomas Kander
Lund University
First Submitted
May 11, 2024
First Posted
May 16, 2024
Study Start
January 16, 2025
Actual (reported)Primary Completion
June 2027
EstimatedThe Relationship Between the Lack of AT-Ⅲ, PC, PS Activity and PICC-related Thrombosis
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Contact the study team to confirm eligibility.
Rockholt MM, Naddi L, Badri AM, Englund E, Kander T. Macro- and microscopic changes in veins with short-term central venous catheters: an observational autopsy study. BMC Anesthesiol. 2024 Jan 2;24(1):5. doi: 10.1186/s12871-023-02380-x.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 28, 2026
Record last verified: 2026-04
Upon reasonable request, de-identified individual participant data from this clinical trial will be shared to facilitate scientific collaboration.
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Source: ClinicalTrials.gov.
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