Genetics in the Progression of Nephropathies

NCT06416761 | Recruiting

• 1 other identifier: GenNefro01
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to:

• AKI
• CKD
• Hypertension
• ADPKD
• CKD-MBD
• Patients with decompensated heart failure undergoing either medical or surgery therapy
• Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation
• glomerular diseases

Conditions

AKI; CKD; Ckd-Mbd; CKD (Chronic Kidney Disease) Stage 5D; ADPKD; Hypertension; Hematologic Malignancy; Bone Marrow Transplant Complications

Keywords

genetic in hypertensive kidney disease; salt intake in BP control and CKD progression; genetic in CKD; endogenous Ouabain as marker of AKI; protein intake restriction in CKD progression; hypertension in allogenic bone marrow transplantation

Outcome Measures

Primary Outcomes (1)

• difference in glomerular filtration rate according to genetic profile

  eGFR value

  from days to 35 years

Study Arms (1)

Patients with acute or chronic nephropathy

1. Patients with chronic nephropathies 2. Patients with acute nephropathy 3. Patients with nephrectomy 4. Candidate Patients to major surgery 5. Patients with decompensated heart failure undergoing either medical or surgical therapy 6. Acute critically ill patients (e.g sepsis, post-operative) 7. Patients with hypertension 8. Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation. 9. Long-term surviving patients who received bone marrow transplantation.

Genetic: genetic polymorphisms

Interventions

genetic polymorphisms GENETIC

Patients with acute or chronic nephropathy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study will evaluate different groups of adult patients: 1. Patients with chronic nephropathy 2. Patients with acute nephropathy 3. Patients with nephrectomy 4. Candidate Patients to major surgery 5. Patients with decompensated heart failure undergoing either medical or surgical therapy 6. Acute critically ill patients (e.g sepsis, post-operative) 7. Patients with hypertension 8. Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation. 9. Long-term surviving patients who received bone marrow transplantation.

You may qualify if:

• presence of specific renal disease

You may not qualify if:

• to be evaluated in the different sub-protocols

Sponsors & Collaborators

• Ospedale San Raffaele: lead

Study Sites (1)

IRCCS Ospedale San Raffaele

Milan, 20132, Italy

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

blood , urine and sample of renal tissue

MeSH Terms

Conditions

Chronic Kidney Disease-Mineral and Bone Disorder; Renal Insufficiency, Chronic; Polycystic Kidney, Autosomal Dominant; Hypertension; Hematologic Neoplasms

Interventions

Polymorphism, Genetic

Condition Hierarchy (Ancestors)

Rickets; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Calcium Metabolism Disorders; Vitamin D Deficiency; Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Hyperparathyroidism, Secondary; Hyperparathyroidism; Parathyroid Diseases; Endocrine System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Renal Insufficiency; Polycystic Kidney Diseases; Kidney Diseases, Cystic; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Ciliopathies; Genetic Diseases, Inborn; Vascular Diseases; Cardiovascular Diseases; Neoplasms by Site; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases

Intervention Hierarchy (Ancestors)

Genetic Variation; Genetic Phenomena

Central Study Contacts

Chiara Livia Lanzani, prof

CONTACT

+393408163279; lanzani.chiara@hsr.it

Laura Zagato, biologist

CONTACT

+390226435745; zagato.laura@hsr.it

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Assistant

Study Record Dates

• First Submitted: May 11, 2024
• First Posted: May 16, 2024
• Study Start: May 19, 2006
• Primary Completion (Estimated): May 19, 2040
• Study Completion (Estimated): May 19, 2041
• Last Updated: May 16, 2024

Record last verified: 2024-05

Locations

IT (1)