NCT06413160

Brief Summary

Cardiovascular-renal-metabolic (CRM) syndrome is defined as a systemic disorder with a collection of related signs and symptoms attributable to the coexistence of multiple cardiovascular, renal and metabolic disease with a common underlying pathophysiology in one individual. Surveying this syndrome in a large population in Jordan aims at studying the risk factors, components and stages of the syndrome, thus helping early screening, diagnosing and treating disease and its risk factors.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
18mo left

Started Jul 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 6, 2024

Completed
8 days until next milestone

First Posted

Study publicly available on registry

May 14, 2024

Completed
2.1 years until next milestone

Study Start

First participant enrolled

July 1, 2026

Expected
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2027

4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

December 30, 2025

Status Verified

December 1, 2025

Enrollment Period

1.2 years

First QC Date

May 6, 2024

Last Update Submit

December 22, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Prevalence of cardiovascular-renal-metabolic syndrome

    1. CVD A. Coronary heart disease: Silent and clinical CAD (chronic stable coronary disease, acute coronary disease \[ST-elevation myocardial infarction and non-ST-elevation acute coronary syndrome\]. B. Heart failure. C. Atrial fibrillation. D. Stroke. E. Peripheral artery disease 2. Renal: chronic kidney disease 3. Metabolic: A. Obesity/ B. Diabetes mellitus (DM).

    From date of study entry through study completion, an average of 1 year

Secondary Outcomes (1)

  • Elevated levels of blood markers

    From date of study entry through study completion, an average of 1 year

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Consecutive individuals (N=10,000) visiting allocated medical laboratories in North, Center, and South sections of the country during public free blood testing campaigns planned in August 2024 to June 2025.

You may qualify if:

  • Adults (age 18 years and above).
  • Willing to sign an informed consent.

You may not qualify if:

  • None.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Istishari Hospital

Amman, 11184, Jordan

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Centrifuged plasma obtained from peripheral blood sample of the participants

Study Officials

  • Ayman Hammoudeh, MD, FACC

    Istisjhari Hospital

    STUDY DIRECTOR
  • Imad A Alhaddad, MD, FACC

    Jordan Hospital

    STUDY CHAIR

Central Study Contacts

Ayman Hammoudeh, MD, FACC

CONTACT

Imad A Alhaddad, MD, FACC

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director, Department of Clinical Research

Study Record Dates

First Submitted

May 6, 2024

First Posted

May 14, 2024

Study Start (Estimated)

July 1, 2026

Primary Completion (Estimated)

August 31, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

December 30, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations