The All Ireland Infectious Diseases Cohort Project

NCT06410053 | Recruiting

• 1 other identifier: AIID Cohort
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 9

Brief Summary

The All-Ireland Infectious Diseases (AIID) Cohort is a multicentre, prospective, longitudinal observational cohort that enrols consecutive adult subjects attending participating institutions for infectious disease services. This is an ongoing prospective observational cohort of unlimited duration.

Conditions

Infectious Disease

Keywords

Human Immunodeficiency virus; COVID-19; Viral hepatitis; Skin and soft tissue infections; Bone infection

Outcome Measures

Primary Outcomes (1)

• Establishment of data rich cohort

  Overall number of recruited participants and number of recruited participants with major conditions (COVID-19, HIV, TB)

  through study completion, an average of 1 year

Secondary Outcomes (2)

• Cohort retention

  through study completion, an average of 1 year

• Cohort associated metadata

  through study completion, an average of 1 year

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult patients attending Clinical Services relating to infectious diseases at participating hospitals in Ireland who provide written informed consent.

You may qualify if:

• ≥ 18 years of age patients attending clinical services of participating institutions with issues related to infectious diseases.
• Willing and able to provide informed consent or
• Provide deferred assent if an incapacitated or unconscious patient is unable to provide informed consent

You may not qualify if:

• Patients under 18 years of age
• Patients with learning disabilities, mental illness, or dementia

Sponsors & Collaborators

• University College Dublin: lead
• Beaumont Hospital: collaborator
• Children's Health Ireland: collaborator
• Cork University Hospital: collaborator
• Mater Misericordiae University Hospital: collaborator
• Our Lady of Lourdes Hospital, Drogheda: collaborator
• St. James's Hospital, Ireland: collaborator
• St. Luke's Hospital, Ireland: collaborator
• St Vincent's University Hospital, Ireland: collaborator
• Wexford General Hospital: collaborator

Study Sites (9)

Cork University Hospital

Cork, Ireland

RECRUITING

Our Lady of Lourdes Hospital, Drogheda

Drogheda, Ireland

RECRUITING

St Vincent's University Hospital, Ireland

Dublin, D4, Ireland

RECRUITING

Mater Misericordiae University Hospital

Dublin, Dublin 7, Ireland

RECRUITING

Beaumont Hospital

Dublin, Ireland

RECRUITING

Children's Health Ireland at Crumlin

Dublin, Ireland

RECRUITING

St James's Hospital

Dublin, Ireland

RECRUITING

St Luke's General Hospital, Kilkenny

Kilkenny, Ireland

RECRUITING

Wexford General Hospital

Wexford, Ireland

RECRUITING

Related Links

• AIID Cohort Project

Biospecimen

Retention: SAMPLES WITH DNA

1. Blood sample to be prepared as plasma, serum and viable peripheral blood mononuclear cells (PBMC) for cryopreservation. 2. Respiratory samples (where relevant e.g., subject with respiratory viral infection or pulmonary TB) 3. Stool sample for later microbiome analysis (optional) 4. Urine 5. Swabs, including mucosal (e.g., ano-genital, naso-pharyngeal) and superficial (skin). In addition, where subjects undergo lumbar puncture testing as part of routine care, any excess available sample may also be stored. These stored samples provide the opportunity for future research studies investigating host factors associated with the response to infection.

MeSH Terms

Conditions

Communicable Diseases; Acquired Immunodeficiency Syndrome; COVID-19; Soft Tissue Infections

Condition Hierarchy (Ancestors)

Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; HIV Infections; Blood-Borne Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Patrick Mallon, PhD, FRCPI

  UCD

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Aoife Cotter, PhD

CONTACT

aoife.cotter@ucd.ie

Alan Macken

CONTACT

alan.macken@ucd.ie

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 5, 2023
• First Posted: May 10, 2024
• Study Start: March 1, 2011
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: May 10, 2024

Record last verified: 2024-05

Locations

IE (9)