Evaluation of 3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning

NCT06409000 | Completed DMC

• 3 other identifiers: 19-012790NCI-2022-09578ROA1971
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates if three dimensional (3D) surface images can be used instead of the standard computed tomography (CT) scans for treatment planning in electron radiation therapy. 3D scanning has previously been used by several groups to design patient-specific devices to be 3D printed, and as has shown excellent agreement with CT obtained surfaces. Using 3D surface imaging instead of x-ray based CT, benefits include: no ionizing radiation used to produce images, shorter time between patient consultation and treatment, and ability to produce and evaluate patient-specific devices for electron therapy earlier in the treatment planning process. This study may help researchers learn how 3D surface scanning may be used to produce a virtual CT image of patient surfaces, and accurately replace traditional planning CT for treatment planning of electron based radiation therapy.

Conditions

Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm

Outcome Measures

Primary Outcomes (3)

• Dose distribution agreement between virtual and planning computed tomography (CT) datasets

  The various three dimensional (3D) scans and CTs of the phantoms will be qualitatively assessed for agreement and accuracy to determine best practice, but there will be no statistical significance tested for. Will be conducted entirely on inanimate, plastic, anthropomorphic models (phantoms).

  Up to 2 months

• Geometric agreement between virtual and planning CT datasets

  Will test for distance to agreement differences between 3D scans taken at different time points (consultation, simulation, and treatment).

  Up to 2 months

• Geometric agreement between 3D scans taken at different time points

  Various dose metrics will be extracted from each of the three types of dose distribution: the ground truth CT based dose distribution, the 3D scan based virtual CT dose distributions, and the flat water phantom based dose distributions. Paired statistical tests will be used for each metric to test for significant differences between the various methods used to calculate the dose distributions.

  Up to 2 months

Study Arms (1)

Observational (3D surface scans, medical records)

Patients undergo 3D surface scans on study. Patient's medical records are also reviewed on study.

Other: Electronic Health Record Review; Procedure: Three-Dimensional Imaging

Interventions

Electronic Health Record Review OTHER

Medical records reviewed

Observational (3D surface scans, medical records)

Three-Dimensional Imaging PROCEDURE

Undergo 3D surface scans

Also known as: 3-D Imaging, 3-Dimensional Imaging, 3D Imaging, Medical Imaging, Three Dimensional

Observational (3D surface scans, medical records)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients being treated with electron radiation therapy at Mayo Clinic.

You may qualify if:

• Adults (18 years old or older)
• Capable of consent
• Receiving electron therapy and a planning CT scan
• Consent to two 3D surface scans of treatment area

You may not qualify if:

• Pediatric patients
• Mentally incapable of study consent
• Receiving electron radiation for a breast cancer boost
• Receiving electrons for total skin electron therapy
• Patients with epilepsy or other seizure disorders

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

Location

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Interventions

Imaging, Three-Dimensional

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Daniel P. Harrington, MS

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 7, 2024
• First Posted: May 10, 2024
• Study Start: January 19, 2021
• Primary Completion: February 5, 2026
• Study Completion: February 5, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Locations

US (1)