Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia

NCT06405594 | Recruiting

• 1 other identifier: 2044118-1
• Study Type: interventional
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life. By seeking to better understand post-stroke aphasia, this project lays the groundwork for development of new interventions, and aligns with NIDCD's priority areas 1 (understanding normal function), 2 (understanding diseases), and 3 (improving diagnosis, treatment, and prevention).

Conditions

Aphasia, Acquired; Stroke; Healthy Aging

Outcome Measures

Primary Outcomes (3)

• Accuracy

  Response accuracy for each experimental condition will be measured

  through the completion of the study, an average of 1 year

• Response time

  Response times for each experimental condition will be measured

  through the completion of the study, an average of 1 year

• Brain activity

  Patterns of brain activity (using magnetoencephalography and MRI) will be measured for each experimental condition

  through the completion of the study, an average of 1 year

Study Arms (1)

Language condition

EXPERIMENTAL

All participants will receive this arm. In this arm, the intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.

Behavioral: Language Condition

Interventions

Language Condition BEHAVIORAL

The intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.

Language condition

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 18 years of age
• Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke).
• Neurotypical adults need to be either young (ages 18-30 years) or older (\> 60 years)
• Native (or primary) speakers of English

You may not qualify if:

• Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia
• do not speak English fluently

Sponsors & Collaborators

• University of Maryland, College Park: lead
• McMaster University: collaborator

Study Sites (1)

University of Maryland

College Park, Maryland, 20742, United States

RECRUITING

MeSH Terms

Conditions

Aphasia; Stroke

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Yasmeen Faroqi-Shah, PhD

  University of Maryland

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yasmeen Faroqi-Shah, PhD

CONTACT

3014054229; yfshah@umd.edu

Robert Slevc, PhD

CONTACT

(301) 405-5835; slevc@umd.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: All participants will receive the same intervention (language condition) and a single arm (language condition)

Study Record Dates

• First Submitted: May 1, 2024
• First Posted: May 8, 2024
• Study Start: August 1, 2024
• Primary Completion (Estimated): June 1, 2028
• Study Completion (Estimated): June 1, 2029
• Last Updated: September 3, 2024

Record last verified: 2024-08

Locations

US (1)