Nutrient Timing in Connection to Evening Exercise

NCT06400836 | Completed

• 1 other identifier: Dnr: 2022-03056-01
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Physical exercise (PE) significantly influences insulin sensitivity (IS), glucose control and overall metabolic health. While PE effectively enhances IS and glucose regulation, the timing of nutrient intake, before and after exercise, plays a crucial role in modulating its effects. The aim of this study is to evaluate how pre- or post-evening exercise carbohydrate (CHO) ingestion influences glucose metabolism and substrate oxidation (fat/CHO) during exercise and after exercise in athletes during the nocturnal period and the morning after during an oral glucose tolerance test (OGTT).

Conditions

Carbohydrate Metabolism; Lipid Metabolism; Blood Glucose; Oral Glucose Tolerance Test

Keywords

Athletes; Continuous glucose monitoring; Exercise; Metabolism; Nutrition

Outcome Measures

Primary Outcomes (1)

• To investigate change in glucose tolerance during a 75g glucose, 120 min oral glucose tolerance test (OGTT)

  To quantify participants' glucose tolerance, the change in plasma glucose levels (mmol/L) will be measured over a 120-minute period following the ingestion of a standardized 75g glucose solution during an OGTT.

  Comparing the change in glucose tolerance during the OGTT between baseline (no exercise) week 0, compared to interventions week 1 and week 2 involving previous evening exercise, with carbohydrates consumed either before or after exercise.

Secondary Outcomes (1)

• To investigate substrate oxidation during the oral glucose tolerance test (OGTT)

  Comparing the change in substrate oxidation during the OGTT between baseline (no exercise) week 0, compared to interventions week 1 and week 2 involving previous evening exercise with carbohydrates being consumed either before or after exercise.

Other Outcomes (3)

• To investigate performance capacity during a cycle ergometer time trial (TT).

  Comparing the change in performance capacity between the interventions involving carbohydrates being consumed either before (week 1) or after the time trial (week 2). Note that respective arm will be randomized.

• To investigate substrate oxidation during 50 min submaximal evening exercise.

  Comparing the change in substrate oxidation between the interventions involving previous evening exercise with carbohydrates being consumed either before (week 1) or after exercise (week 2). Note that respective arm will be randomized.

• To investigate nocturnal glucose regulation.

  Comparing the change in glucose levels (mmol/L) during the period 21:00-06:00 between baseline (no exercise) week 0, compared to interventions week 1 and week 2 involving previous evening exercise, with CHO consumed either before or after exercise.

Study Arms (2)

Carbohydrate drink

ACTIVE COMPARATOR

All study participants will receive the carbohydrate (CHO) drink and the placebo in a randomized, doubleblind crossover fashion. The CHO drink and placebo products have similar appearance and taste.

Other: Carbohydrate timing - carbohydrate intake before or after exercise

Placebo

PLACEBO COMPARATOR

All study participants will receive the carbohydrate (CHO) drink and the placebo in a randomized, double-blind crossover fashion. The CHO drink and placebo products have similar appearance and taste.

Other: Carbohydrate timing - carbohydrate intake before or after exercise

Interventions

Carbohydrate timing - carbohydrate intake before or after exercise OTHER

The study aims to investigate how pre- or post evening exercise carbohydrate ingestion influences glucose metabolism and substrate oxidation (fat/CHO) during exercise and after exercise in athletes during the nocturnal period (21:00-06:00) and the morning after during an 120 minute oral glucose tolerance test (OGTT).

Carbohydrate drink; Placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Females and males
• years
• Endurance fitness level of ≥40 mL O2/kg/min.
• Signed informed consent

You may not qualify if:

• Medical treatment and/or nutritional supplements that may affect glucose tolerance, substrate oxidation and performance capacity

Sponsors & Collaborators

• Göteborg University: lead
• Örebro University, Sweden: collaborator

Study Sites (1)

Department of Food and Nutrition, and Sport Science, Centre for Health and Performance, University of Gothenburg, Gothenburg, Sweden

Gothenburg, Bohuslän, 405 30, Sweden

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Stefan Pettersson, Assoc. Prof.

  Department of Food and Nutrition, and Sport Science, University of Gothenburg, Sweden

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Double (Participant, Investigator)
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Crossover Assignment Randomised double-blind cross-over study

Study Record Dates

• First Submitted: April 11, 2024
• First Posted: May 6, 2024
• Study Start: January 10, 2022
• Primary Completion: September 2, 2022
• Study Completion: September 2, 2022
• Last Updated: May 6, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)