In Patients With Carpal Tunnel Syndrome, Median Nerve Conduction is Evaluated After Nerve Mobilizations

NCT06399484 | Not Yet Recruiting

• 1 other identifier: PI23/437
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This project is linked to the line of research on carpal tunnel syndrome, of the PhysiUZerapy research group, belonging to the University of Zaragoza. Within this line, the biomechanical and physiological effect of the proposed technique has been investigated, both in healthy subjects, in cadavers and in patients with carpal tunnel syndrome (CTS), resulting in the reading of 2 doctoral theses, the publication of 9 articles in high-impact journals. and the patent for a splint for the treatment of pathology. This project aims to provide information that is still lacking on the immediate effect of these techniques in patients with CTS. For this, there will be three groups of patients from the Lozano Blesa University Clinical Hospital distributed randomly. In two of the groups, sliding and neural tension techniques will be carried out (case group). The remaining group (control group) will be taken as a reference by performing a placebo treatment. Before and after carrying out these techniques, electrophysiological data will be collected to be able to compare them. This comparison is based on highlighting the differences between the data before the techniques and after, as well as between the case group and the control group.

Conditions

Carpal Tunnel Syndrome

Outcome Measures

Primary Outcomes (5)

• Distal motor latency (APB) (ms)

  Before and immediately after the intervention

• Motor amplitude (APB) (mV)

  Before and immediately after the intervention

• Median motor velocity (m/s)

  Before and immediately after the intervention

• Median sensory conduction (digit II) (13 cm) (m/sec)

  Before and immediately after the intervention

• Sensory amplitude (µV)

  Before and immediately after the intervention

Study Arms (2)

Neural mobilization group

EXPERIMENTAL

Manual mobilizations of the median nerve.

Other: Manual mobilizations of the median nerve

Placebo group

PLACEBO COMPARATOR

wrist movements no producing sliding of the median nerve

Other: Wrist movements

Interventions

Manual mobilizations of the median nerve OTHER

Slippage of the median nerve in the wrist: the subject's starting position (P0) will be recumbent supine with the cervical spine in a neutral position, the shoulder girdle in neutral position, 30º of glenohumeral abduction in neutral rotation, 90º of elbow flexion, prone-supination of the neutral forearm, wrist and fingers in neutral position. From this position the movements will be 1) Glenohumeral abduction up to 90º; 2) Glenohumeral external rotation to the frontal plane; 3) Supination of the forearm; 4) Extension of the wrist and fingers; 5) Elbow extension. This position is will combine with an ipsilateral cervical inclination (distal sliding). The proximal slide is carried out bringing the fingers of the hand towards the flexion while performing a contralateral cervical tilt. Median nerve tension: the starting position and movements are the same described above but this time it will be done with contralateral cervical tilt.

Neural mobilization group

Wrist movements OTHER

Movements of the wrist joint will be performed as a placebo treatment

Placebo group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being over 18 years
• Present carpal tunnel syndrome diagnosed by electroneurogram
• Have understanding and communication skills
• Give consent to participate in the study

You may not qualify if:

• Have received previous surgery on the hand or wrist
• Present a severe limitation of movement in any of the joints of the affected upper limb
• Not signing the informed consent

Sponsors & Collaborators

• Universidad de Zaragoza: lead

Study Sites (1)

Hospital Clínico Universitario Lozano Blesa

Zaragoza, 50009, Spain

Location

MeSH Terms

Conditions

Carpal Tunnel Syndrome

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physiotherapist, PhD

Study Record Dates

• First Submitted: April 25, 2024
• First Posted: May 3, 2024
• Study Start: June 15, 2024
• Primary Completion: September 15, 2024
• Study Completion: December 15, 2024
• Last Updated: May 3, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)