Engaging College Students in Developing and Testing a Video-based Intervention for HPV Vaccination Promotion

NCT06397378 | Recruiting

• 2 other identifiers: MSUSTUDY10264PD66847
• Study Type: interventional
• Target: 123
• Locations: 1 country
• Sites: 1

Brief Summary

HPV vaccines offer hope against HPV-associated cancers for males and females; however, the rate of vaccination has not reached projected public health goals. This study will engage key stakeholders in the research process to co-design and pilot testing a video-based intervention addressing low HPV vaccination rates among college students The intervention and its approach have the potential to reduce health disparities in HPV-associated cancers in young adults via low-cost technology and timely intervention.

Conditions

N/A - Healthy Subjects

Keywords

video intervention; HPV vaccination rate; HPV infection; college students

Outcome Measures

Primary Outcomes (6)

• Participants' HPV vaccination intention

  The investigators will assess participants' intention to receive HPV vaccines before and after watching HPV vaccine-related videos, t

  through study completion, an average of 1 year

• Participants' HPV vaccine uptake

  Participants will be asked if they received any HPV vaccines after watching the videos.

  through study completion, an average of 1 year

• Participants' attitude toward receiving the HPV vaccines

  Participants' attitude toward receiving HPV vaccines will be assessed before and after watching videos.

  through study completion, an average of 1 year

• Participants' subjective norms

  Participants' subjective norms regarding receiving HPV vaccines will be assessed before and after watching videos.

  through study completion, an average of 1 year

• Participants' perceived behavioral controls

  Participants' perceived behavioral control regarding receiving HPV vaccines will be assessed before and after watching videos.

  through study completion, an average of 1 year

• Participants' satisfaction

  participants' satisfaction about the interventions.

  through study completion, an average of 1 year

Study Arms (2)

Group using CDC factsheet

ACTIVE COMPARATOR

We did not develop this intervention. Instead, we will use information from the CDC website on HPV and the HPV vaccine and convert it into a narrated voiceover video to ensure the information is delivered in the same format as our video-based intervention.

Other: CDC HPV Fact Sheet

Group using videos

EXPERIMENTAL

Ninety-three college students will be randomly assigned to three groups (31 participants in each video group Vs. 30 participants in the CDC group) to watch the created videos. The videos will be presented in randomized order and distributed to participants to minimize bias.

Other: short videos related to HPV and the HPV vaccine

Interventions

short videos related to HPV and the HPV vaccine OTHER

Eight college students created and developed four videos on human papillomavirus (HPV) and the HPV vaccine, designed to increase their knowledge and attitude, shape subjective norms, enhance perceived behavioral control, and strengthen intentions to receive the HPV vaccine. Two months after the video intervention, we will follow up with participants to collect their self-reported vaccine uptake status. Outcomes will be compared with those of another group whose participants will watch a video presenting CDC information on HPV and the HPV vaccine, adapted into a narrated voiceover format.

Group using videos

CDC HPV Fact Sheet OTHER

We did not develop this intervention. Instead, we will use information from the CDC website on HPV and the HPV vaccine and convert it into a video with a narrated voiceover format. Because our student advisory board will develop four short videos, participants who are randomly assigned to the CDC fact sheet group will watch the converted CDC video four times to ensure that all groups are exposed to the same number of videos. Here is the CDC link: https://www.cdc.gov/hpv/vaccines/?CDC\_AAref\_Val=https://www.cdc.gov/hpv/parents/vaccinesafety.html

Group using CDC factsheet

Eligibility Criteria

• Age: 18 Years - 26 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Sponsors & Collaborators

• Michigan State University: lead

Study Sites (1)

Michigan State University

East Lansing, Michigan, 48824, United States

RECRUITING

Related Publications (1)

• Liu C, Chen AC, Rhodes N, Ewoldsen D, Arcoleo K. Evaluating the preliminary effectiveness of a video-based intervention for HPV vaccination promotion among college students aged 18-26: study protocol for a pilot randomised controlled trial. BMJ Open. 2025 Nov 16;15(11):e102235. doi: 10.1136/bmjopen-2025-102235.

  PMID: 41248380 DERIVED

MeSH Terms

Conditions

Papillomavirus Infections

Condition Hierarchy (Ancestors)

Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Communicable Diseases; Infections; DNA Virus Infections; Virus Diseases; Tumor Virus Infections; Genital Diseases; Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

ChengChing Hiya Liu, Ph. D.

CONTACT

626-566-4835; chengliu@msu.edu

Angela Chia-Chen Chen, Ph.D.

CONTACT

5173534747; chenang6@msu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: This study has been approved by the host university's Biomedical and Health Institutional Review Board (Study ID: STUDY00010264). We propose conducting a two-phase, mixed-methods research project to co-develop a culturally and developmentally appropriate video-intervention (Phase 1) with a Student Advisory Board (SAB) composed of eight college students with diverse background (sex, age, discipline). Once the videos are finalized, we will engage the SAB in the Phase 2 activities aimed to examine the feasibility, acceptability, and preliminary effectiveness of a RCT among college students aged 18-26.

Study Record Dates

• First Submitted: April 12, 2024
• First Posted: May 2, 2024
• Study Start: August 16, 2024
• Primary Completion: September 5, 2025
• Study Completion (Estimated): June 30, 2026
• Last Updated: September 25, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: December 2025
• Access Criteria: To increase the robustness of the study design and results, the team member who handles data and analysis will be blinded to the assignment of participants in the respective study arms. Each participant will be assigned a unique ID linked to respective random group assignments. One unblinded team member will be selected to make reminder calls; this staff member will not be involved in intervention delivery or data entry, cleaning, or analysis. The PI will closely monitor the procedures to ensure high treatment fidelity.

Locations

US (1)