NCT06390644

Brief Summary

This randomized controlled trial aims to investigate the efficacy of periorbital massage therapy in alleviating symptoms and improving clinical outcomes in patients diagnosed with dry eye disease.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Oct 2023

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2023

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2024

Completed
24 days until next milestone

First Submitted

Initial submission to the registry

April 25, 2024

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 30, 2024

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2024

Completed
Last Updated

April 30, 2024

Status Verified

April 1, 2024

Enrollment Period

6 months

First QC Date

April 25, 2024

Last Update Submit

April 25, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Schirmer Strips

    Schirmer's test is used to determine whether the eye produces enough tears to keep it moist. The test is performed by placing filter paper inside the lower lid of the eye. After 5 minutes, the paper is removed and tested for its moisture content.

    12 Months

Secondary Outcomes (1)

  • OSDI Questionnaire

    12 Months

Study Arms (2)

Periorbital Massage Therapy

EXPERIMENTAL

Participants in this arm will receive periorbital massage therapy administered by a trained practitioner.

Diagnostic Test: Periorbital Massage Therapy

Control Group (Standard Care)

OTHER

Participants in this arm will receive standard care for dry eye disease.

Other: Control Group (Standard Care)

Interventions

Participants in this arm will receive periorbital massage therapy administered by a trained practitioner. The massage technique will involve gentle circular motions around the eye sockets and brow bone area, aiming to improve eyelid and tear gland function.

Periorbital Massage Therapy

Participants in this arm will receive standard care for dry eye disease, which include artificial tears. They will not receive periorbital massage therapy."

Control Group (Standard Care)

Eligibility Criteria

Age20 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Symptoms of dry eye (such as burning, dryness or foreign body sensation)
  • Ocular signs of dry eye (such as tear film instability, reduced tear production or meibomian gland dysfunction)
  • Patients having moderate and severe dry eye disease according to schirmer test Willing and able to comply with the study protocol

You may not qualify if:

  • Active ocular infection
  • Ocular surgery within past 3 months
  • Use of contact lenses
  • Use of systemic medications that can affect tear production or tear quality
  • Pregnancy or lactation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Usman Saleem Hospital and Fouzia Maternity Home Address: Usman Saleem Hospital and Fouzia Maternity Home

Lahore, Punjab Province, Pakistan

Location

MeSH Terms

Conditions

Dry Eye Syndromes

Interventions

Control GroupsStandard of Care

Condition Hierarchy (Ancestors)

Lacrimal Apparatus DiseasesEye Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Research DesignEpidemiologic MethodsInvestigative TechniquesResearch DesignMethodsQuality Indicators, Health CareQuality of Health CareHealth Services AdministrationHealth Care Quality, Access, and Evaluation

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

April 25, 2024

First Posted

April 30, 2024

Study Start

October 1, 2023

Primary Completion

April 1, 2024

Study Completion

September 30, 2024

Last Updated

April 30, 2024

Record last verified: 2024-04

Data Sharing

IPD Sharing
Will not share

Locations