Impact of Hepatectomy on HCC Recurrence

NCT06390228 | Completed

• 2 other identifiers: 2023-RE-285No. 82172071
• Study Type: observational
• Target: 197
• Locations: 1 country
• Sites: 1

Brief Summary

Hepatectomy is the first option for the treatment of hepatocellular carcinoma(HCC) at CNLC Ib stage. HCC patients who undergo curative hepatectomy may experience varying remnant liver volumes and thus leads to different oncological outcomes.

Conditions

Hepatocellular Carcinoma Stage I; Recurrence

Keywords

Hepatocellular Carcinoma; recurrence; hepatectomy

Outcome Measures

Primary Outcomes (1)

• recurrence-free survival

  the time from the time of radical surgery to the time of HCC recurrence

  2019.1-2023.8

Study Arms (2)

Major hepatectomy

Major hepatectomy was defined as the removal of four or more Couinaud's liver segments.

Procedure: Major hepatectomy

Minor hepatectomy

Minor hepatectomy was defined as the removal of three or fewer Couinaud's segments.

Interventions

Major hepatectomy PROCEDURE

the extent of liver resection

Also known as: minor hepatectomy

Major hepatectomy

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

a final sample of 197 patients was included in this study. Among these patients, 70 underwent MAH (including 62 right hepatectomies, 4 extended right hepatectomies, and 4 extended left hepatectomies), while 127 patients underwent MIH (including 32 left hepatectomies, 10 right anterior hepatectomies, 17 right posterior hepatectomies, 11 mesohepatectomies, 20 left lateral hepatectomies, 21 right partial hepatectomies, 3 left partial hepatectomies, and 13 single segment hepatectomies). Using PSM analysis, 49 pairs of matched patients were identified from each group to compare outcomes.

You may qualify if:

• histologically confirmed solitary HCC with a size of ≥5 cm
• Eastern Cooperative Oncology Group score of 0 or 1
• preoperative indocyanine green retention rate at 15 minutes ≤15% and Child-Pugh A classification
• no evidence of vascular invasion or extrahepatic disease.

You may not qualify if:

• not diagnosed with HCC or had an HCC measuring \<5 cm
• had confirmed tumor metastases or macrovascular invasion based on radiological examinations
• died within 90 days after surgery were excluded

Sponsors & Collaborators

• Anhui Medical University: lead
• National Natural Science Foundation of China: collaborator

Study Sites (1)

Anhui Provincial Hospital

Hefei, Anhui, 230001, China

Location

MeSH Terms

Conditions

Carcinoma, Hepatocellular; Recurrence

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Dalong Yin, Ph.D

  The First Affiliated Hospital of University of Science and Technology of China

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: April 24, 2024
• First Posted: April 30, 2024
• Study Start: January 1, 2019
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: April 30, 2024

Record last verified: 2024-04

Locations

CN (1)