NCT06386341

Brief Summary

The aim of this observational study is to evaluate the impact of maxillomandibular advancement surgery on the quality of life in patients treated with obstructive sleep apnea. The main question it aims to answer is: Does MMA surgery in OSA patiënts improve their quality of life? Patients will answer online surverys about their QoL and there will be data collected like length, weight and blood pressure.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for all trials

Timeline
3mo left

Started Aug 2023

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress92%
Aug 2023Aug 2026

Study Start

First participant enrolled

August 2, 2023

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

April 23, 2024

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 26, 2024

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 2, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 2, 2026

Last Updated

April 26, 2024

Status Verified

August 1, 2023

Enrollment Period

3 years

First QC Date

April 23, 2024

Last Update Submit

April 23, 2024

Conditions

Keywords

Sleep Apnea, ObstructiveQuality of LifeSurgery, Oral

Outcome Measures

Primary Outcomes (1)

  • SF-36

    Survey

    5 minutes

Secondary Outcomes (5)

  • OHIP-14

    5 minutes

  • ESS

    5 minutes

  • FOSQ

    5 minutes

  • EQ-5D-3L

    5 minutes

  • OQLQ

    5 minutes

Study Arms (2)

Intervention group

Patiënts who underwent MMA surgery for OSA.

Procedure: Maxillomandibular Advancement Surgery

Control group

Patiënts who underwent MMA surgery for other reasons than OSA.

Procedure: Maxillomandibular Advancement Surgery

Interventions

Surgery where the upper and lower jaw are repositioned.

Control groupIntervention group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients undergoing maxillomandibular advancement surgery for OSA (intervention group) or other reasons (control group).

You may qualify if:

  • years and older.
  • Ability to speak, read and write Dutch.
  • Ability to follow up.
  • Ability to use a computer with internet connection and windows-software for uploading data
  • and online questionnaires.
  • Diagnosis with OSA. (only for the intervention group)
  • Expected to maintain current lifestyle (sports, medicine, diet etc.).
  • Qualifies for MMA surgery
  • Patients who provide informed consent

You may not qualify if:

  • Patients who do not qualify for MMA surgery
  • Medication used/ related to sleeping disorders.
  • Night or shifting work.
  • Severe chronic heart failure.
  • Medical history of known causes of tiredness by day or severe sleep disruption (insomnia,
  • PLMS, Narcolepsy).
  • Seizure disorder.
  • Known medical history of mental retardation, memory disorders or psychiatric disorders.
  • Patients with old type of pacemakers (It is possible that old types of peacemakers are not
  • Compatible with the electromagnetic radiation of the electronics of the SPT).
  • Shoulder, neck and back complaints.
  • Reversible morphological upper airway abnormalities (e.g. enlarged tonsils).
  • Inability to provide informed consent.
  • Simultaneous use of other treatment modalities to treat OSA.
  • Previous treatment for OSA with MRA or SPT
  • +3 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Diakonessenhuis

Utrecht, 3582KE, Netherlands

RECRUITING

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea SyndromesApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 23, 2024

First Posted

April 26, 2024

Study Start

August 2, 2023

Primary Completion (Estimated)

August 2, 2026

Study Completion (Estimated)

August 2, 2026

Last Updated

April 26, 2024

Record last verified: 2023-08

Data Sharing

IPD Sharing
Will not share

Locations