Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section

NCT06383923 | Unknown

• 1 other identifier: BYSYDL2022015
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.Identify the risk factors for Placenta accreta spectrum (PAS) disorders in women without prior caesarean section (CS).
2. 2.Clarify the prognostic factors of the disease and explore individualized treatment options to improve the prognosis of patients with this type of disease;
3. 3.Use the cohort's biological sample database to conduct serology, cytology, and histology studies to explore the abnormal uterine immune microenvironment and the impact on uterine spiral artery remodeling in non-scar uterine-placenta accreta disease.

Conditions

Placenta Accreta Spectrum

Outcome Measures

Primary Outcomes (1)

• Placenta Accreta Spectrum

  Clinical diagnosis and classification standards are based on the diagnostic standards recommended by FIGO in 2019

  2 years

Secondary Outcomes (4)

• Amount of bleeding

  2 years

• Hemostatic measures

  2 years

• hysterectomy

  2 years

• blood transfusion volume

  2 years

Study Arms (1)

pregnant women

pregnant women without prior cesarean section（CS） who had prenatal check-ups and gave birth at the Obstetrics Department of Peking University Third Hospital from January 1, 2023 to December 31, 2024.

Eligibility Criteria

• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will prospectively collect pregnant women without history of cesarean sections who had prenatal check-ups and gave birth at the Obstetrics Department of Peking University Third Hospital from January 1, 2023 to December 31, 2024. The prospective study will exclude those who did not terminate pregnancy or gave birth in our hospital and those who gave birth at \<28 weeks.

You may qualify if:

• Pregnant women without prior cesarean section
• Pregnant women who had prenatal check-ups and gave birth at the Obstetrics Department of Peking University Third Hospital from January 1, 2023 to December 31, 2024

You may not qualify if:

• Pregnant women who did not terminate pregnancy at the Obstetrics Department of Peking University Third Hospital
• Pregnant women who gave birth at \<28 weeks.

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

placenta and uterus

MeSH Terms

Conditions

Placenta Accreta

Condition Hierarchy (Ancestors)

Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Placenta Diseases

Central Study Contacts

Wang Yan, M.D.Ph.D.

CONTACT

13501282029; wjgqhn@263.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 15, 2024
• First Posted: April 25, 2024
• Study Start: January 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: April 25, 2024

Record last verified: 2024-01

Locations

CN (1)