Military Health and Nutrition Examination Study

NCT06380322 | Recruiting

• 1 other identifier: PBRC 2023-034
• Study Type: observational
• Target: 650
• Locations: 1 country
• Sites: 3

Brief Summary

The Military Health and Nutrition Examination Study (MHANES) is a Department of Defense funded study conducted by Pennington Biomedical Research Center and the US Army Research Institute of Environmental Medicine. This cross-sectional study will assess, in a large, diverse sample of Army Service Members (n=600), food and supplement intake, cardiovascular health, body composition, biomarkers of nutritional status, measures of health status, injury prevalence, mental wellbeing, gut microbiome composition, and physical performance outcomes. The proposed study is modeled after the National Health and Nutrition Examination Survey (NHANES) and customized for the Army population.

Conditions

Hypertension; Type 2 Diabetes; Dyslipidemias; Cardiovascular Diseases

Keywords

Diet Quality; Healthy Eating Index; Body Composition; Dietary Supplements; Gut Microbiome; Army Combat Fitness Test

Outcome Measures

Primary Outcomes (2)

• Dietary intake

  24-hour dietary recalls will be collected using ASA24® to measure intake of macronutrients (protein, carbohydrate, and fat) and micronutrients (vitamins and minerals).

  This study will collect one ASA24® recall at visit 1 and a second follow-up 24-hour recall 3-10 days later

• Dietary quality

  24-hour dietary recalls will be collected using ASA24®. Diet quality will be assessed by the healthy eating index (HEI).

  This study will collect one ASA24® recall at visit 1 and a second follow-up 24-hour recall 3-10 days later

Secondary Outcomes (27)

• Depression

  Questionnaires will be administered one time at visit 1 (within 1-2 weeks of study enrollment).

• Anxiety

  Questionnaires will be administered one time at visit 1 (within 1-2 weeks of study enrollment).

• Resilience

  Questionnaires will be administered one time at visit 1 (within 1-2 weeks of study enrollment).

• Posttraumatic stress disorder

  Questionnaires will be administered one time at visit 1 (within 1-2 weeks of study enrollment).

• Self-efficacy

  Questionnaires will be administered one time at visit 1 (within 1-2 weeks of study enrollment).

Study Arms (1)

Active-duty Army Service Members

All measures will be collected one time during the study, except for the dietary recall (measured two times) and urine sample for total daily energy expenditure using doubly labeled water method (measured 3 time).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Active-duty U.S. Army Soldiers (n=600 completers)

You may qualify if:

• U.S. Army Soldiers ≥ 18 years old
• Willing to have biological samples stored for future use
• Willing to have data linked to the Soldier Performance, Health, and Readiness (SPHERE) database

You may not qualify if:

• Soldiers under the age of 18 years
• Soldiers with an inability to understand verbal or written instructions or testing materials in English
• Soldiers relocating or getting out of the Army in the next 30 days
• Pregnant females
• Soldiers currently in Basic Training (BCT) and/or One-Station Unit Training (OSUT)

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead
• U.S. Army Medical Research and Development Command: collaborator

Study Sites (3)

Fort Campbell

Fort Campbell, Kentucky, 42223, United States

RECRUITING

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

RECRUITING

Fort Johnson

Leesville, Louisiana, 71459, United States

RECRUITING

Related Publications (29)

• Karl JP, Margolis LM, Fallowfield JL, Child RB, Martin NM, McClung JP. Military nutrition research: Contemporary issues, state of the science and future directions. Eur J Sport Sci. 2022 Jan;22(1):87-98. doi: 10.1080/17461391.2021.1930192. Epub 2021 Jun 3.

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• Rittenhouse M, Scott J, Deuster P. Healthy Eating Index and Nutrition Biomarkers among Army Soldiers and Civilian Control Group Indicate an Intervention Is Necessary to Raise Omega-3 Index and Vitamin D and Improve Diet Quality. Nutrients. 2020 Dec 31;13(1):122. doi: 10.3390/nu13010122.

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• Eilerman PA, Herzog CM, Luce BK, Chao SY, Walker SM, Zarzabal LA, Carnahan DH. A comparison of obesity prevalence: military health system and United States populations, 2009-2012. Mil Med. 2014 May;179(5):462-70. doi: 10.7205/MILMED-D-13-00430.

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• Clutter CA, Beckman DJ, Wardian JL, Rittel AG, True MW. Are We Missing an Opportunity? Prediabetes in the U.S. Military. Mil Med. 2024 Jan 23;189(1-2):326-331. doi: 10.1093/milmed/usac197.

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• Chao SY, Zarzabal LA, Walker SM, Herzog CM, Eilerman PA, Luce BK, Carnahan DH. Estimating diabetes prevalence in the Military Health System population from 2006 to 2010. Mil Med. 2013 Sep;178(9):986-93. doi: 10.7205/MILMED-D-13-00147.

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• Herzog CM, Chao SY, Eilerman PA, Luce BK, Carnahan DH. Metabolic syndrome in the Military Health System based on electronic health data, 2009-2012. Mil Med. 2015 Jan;180(1):83-90. doi: 10.7205/MILMED-D-14-00039.

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• Shrestha A, Ho TE, Vie LL, Labarthe DR, Scheier LM, Lester PB, Seligman MEP. Comparison of Cardiovascular Health Between US Army and Civilians. J Am Heart Assoc. 2019 Jun 18;8(12):e009056. doi: 10.1161/JAHA.118.009056. Epub 2019 Jun 5.

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• US Department of the Army. (2017) Nutrition and Menu Standards for Human Performance Optimization. Army Regulation 40-25.

  BACKGROUND

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• Farina EK, Thompson LA, Knapik JJ, Pasiakos SM, McClung JP, Lieberman HR. Physical performance, demographic, psychological, and physiological predictors of success in the U.S. Army Special Forces Assessment and Selection course. Physiol Behav. 2019 Oct 15;210:112647. doi: 10.1016/j.physbeh.2019.112647. Epub 2019 Aug 8.

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• Cole RE, Jayne JM, O'Connor K, McGraw SM, Beyl R, DiChiara AJ, Karl JP. Development and Validation of the Military Eating Behavior Survey. J Nutr Educ Behav. 2021 Sep;53(9):798-810. doi: 10.1016/j.jneb.2021.04.467. Epub 2021 Jun 30.

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  BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, plasma, serum, urine, and stool samples

MeSH Terms

Conditions

Hypertension; Diabetes Mellitus, Type 2; Dyslipidemias; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Vascular Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Lipid Metabolism Disorders

Study Officials

• Claire E Berryman, PhD, RD

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Claire E Berryman, PhD, RD

CONTACT

(225) 763-3010; Claire.Berryman@pbrc.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 30, 2024
• First Posted: April 23, 2024
• Study Start: August 24, 2024
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: November 12, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (3)