Anorexia Nervosa and Brain in Adolescence

NCT06380257 | Not Yet Recruiting

• 1 other identifier: ANBA
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.

Conditions

Anorexia Nervosa

Outcome Measures

Primary Outcomes (1)

• Neuroimaging

  Transcranial magnetic stimulation (TMS) combined with electroencephalogram (EEG)

  Baseline and at 3 years' follow-up

Secondary Outcomes (1)

• Neuroimaging

  Baseline and at 3 years' follow-up

Other Outcomes (3)

• Psychiatric evaluation

  Baseline and at 3 years' follow-up

• Body composition measurement

  Baseline and at 3 years' follow-up

• Laboratory tests

  Baseline and at 3 years' follow-up

Study Arms (2)

Study group

Adolescents diagnosed with anorexia nervosa or atypical anorexia nervosa.

Other: Observational study methods

Control Group

Healthy adolescents.

Other: Observational study methods

Interventions

Observational study methods OTHER

Neuroimaging, body compostion, laboratory tests and psychiatric interview in study and in control groups.

Control Group; Study group

Eligibility Criteria

• Age: 16 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Target study population is 50 participants. Study group (25 participants) are recruited from North Savo wellbeing services, Adolescent psychiatry outpatient clinic. Control group (25 participants) are recruited from Kuopio restrict lower and upper secondary schools.

You may qualify if:

• Control group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.

You may not qualify if:

• \) glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.

Sponsors & Collaborators

• Kuopio University Hospital: lead

MeSH Terms

Conditions

Anorexia Nervosa

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders

Study Officials

• Virve Kekkonen, M.D.

  Kuopio University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Virve Kekkonen, M.D.

CONTACT

+35817173311; virve.kekkonen@pshyvinvointialue.fi

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist in adolescent psychiatry, clinical lecturer

Study Record Dates

• First Submitted: April 5, 2024
• First Posted: April 23, 2024
• Study Start: September 1, 2024
• Primary Completion (Estimated): August 1, 2030
• Study Completion (Estimated): December 1, 2030
• Last Updated: April 23, 2024

Record last verified: 2024-04