Physical Activity, Sleep and Brain Health Based on the Glymphatic System

NCT06378515 | Recruiting

• 1 other identifier: Glymphactive
• Study Type: observational
• Target: 77
• Locations: 1 country
• Sites: 1

Brief Summary

This study is aiming to analyze the impact of physical activity on neurohydrodynamics and glymphatic activity on young adults. This study is designed as a multicenter descriptive observational study with information collection at two different times: before performing a short exercise routine and during its performance using a wearable wireless device Glymphometer.

Conditions

Brain Diseases

Keywords

glympathic system; brain health; physical activity; neurohydrodynamics

Outcome Measures

Primary Outcomes (1)

• Brain health

  The data collected through the Glymphometer allows us to obtain the variable known as the G-index, which describes the activity of the glymphatic system. This G-index is based on 14 (patented) algorithms. The G-index ranges from 0 to 100, with higher brain health the higher the score Brain health through the G-Index. Data collected through the Glymphometer allows us to obtain the variable known as the G-index, which describes the activity of the glymphatic system. This G-index is based on 14 (patented) algorithms and ranges from 0 to 100, with higher brain health the higher the score.

  Basal, during 15 minutes

Secondary Outcomes (6)

• Physical activity (habitual)

  Basal

• Sleep duration

  Basal

• Sleep Quality

  Basal

• Chronotype

  basal

• Self-reported health status

  Basal

Interventions

Physical activity, postural changes and cognitive tasks OTHER

1. Measuring while patients are sitting in rest for 5 minutes. 2. Supine to stand test: lying down (5 min) standing up (5 min) 3. Repeated sit stand test: sitting (10 sec) ↔ standing (10 sec), changing position every 10 seconds for 5 minutes. 4. Paced breathing in sitting position: letting patients breath 6 breaths/minute (0.1Hz) for 5 minutes. 5. Breath hold manoeuvre in sitting position: 60s normal breathing, then 32s breath hold + 88s normal breathing repeated 3 times. 6. Arithmetic stress test by giving the subject single digit addition. To give the pressure, subject needs to do as many as possible calculation within 1 minute with 1 minute break. This is repeated 3 times.

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: self-representation of gender identity.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

University students

You may qualify if:

• Students enrolled in a bachelor's degree from one of the universities participating in the study.
• Students who consent to participate in the study indicating that they have been informed of all relevant aspects of the study.

You may not qualify if:

• Students under the age of 18.
• Students with cognitive or sensory difficulties or with insufficient command of the language that, in the opinion of the recruiting professional, makes it difficult to understand the questions raised in the surveys, scales or instruments used in the study.

Sponsors & Collaborators

• University of Valencia: lead
• University of Oulu: collaborator

Study Sites (1)

Universitat de València

Valencia, 46010, Spain

RECRUITING

MeSH Terms

Conditions

Brain Diseases; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Raquel Faubel, PhD

  Universitat de València

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raquel Faubel, PhD

CONTACT

+34651430547; raquel.faubel@uv.es

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer in Physiotherapy

Study Record Dates

• First Submitted: April 17, 2024
• First Posted: April 22, 2024
• Study Start: May 1, 2024
• Primary Completion: April 1, 2025
• Study Completion: December 1, 2025
• Last Updated: August 13, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, CSR
• Time Frame: after the data collection
• Access Criteria: Data will be available based on the criteria of the main researcher

Locations

ES (1)