Sinonasal Risk Factors for Occurrence of Unilateral Versus Bilateral Allergic Fungal Rhinosinusitis .

NCT06376071 | Not Yet Recruiting

• 1 other identifier: fungal rhinosiusitis
• Study Type: observational
• Target: 76
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to assess Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhino sinusitis regarding::

1. 1.anatomical variations and correlate radiological finding with intraoperative finding.
2. 2.other associated factors like demographic ,environmental, immunological and climatic risk factors .

Conditions

Allergic Fungal Rhinosinusitis

Outcome Measures

Primary Outcomes (1)

• Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhinosinusitis

  analysis of the risk factors of unilateral versus bilateral allergic fungal rhinosinusitis

  baseline

Interventions

functional endoscopic sinus surgery DIAGNOSTIC_TEST

functional endoscopic sinus surgery for diagnosis the disease

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be divided into two groups: Group (A): including patients with unilateral allergic fungal rhinosinusitis. Group (B): including patients with bilateral allergic fungal rhinosinusitis. Then all patient will subjected to EFSS under general anathesia with wide sinusotomics where intraoperative collection of data will be done as the follow

You may qualify if:

• Denovo cases . any Age Any sex. Patients diagnosed with unilateral or bilateral allergic fungal rhino sinusitis, meeting classic Bent and Kuhn criteria for AFRS:(10).
• Nasal polyposis. Fungi on staining. Eosinophilic mucin without fungal invasion into sinus tissue., Type I hypersensitivity to fungi. Characteristic radiologic findings with soft-tissue differential densities on computed tomographic (CT) scanning

You may not qualify if:

• Diagnosis of benign or malignant neoplasm of the sinonasal cavity. Prior radiation therapy to the head or neck. Significant prior facial trauma. Autoimmune disorder. Craniofacial anomaly. Fungus ball. Immunodeficiency. Cystic fibrosis. Patients unfit for surgery. Previous nasal surgery or recurrent cases .

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Kwon E, O'Rourke MC. Chronic Sinusitis. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK441934/

  PMID: 28722963 BACKGROUND

• Akhondi H, Woldemariam B, Rajasurya V. Fungal Sinusitis. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK551496/

  PMID: 31855340 RESULT

Related Links

• Indian J Otolaryngol Head Neck Surg. 2023 Jun;75(2):571-578. doi: 10.1007/s12070-022-03338-0. Epub 2022 Dec 17

MeSH Terms

Conditions

Allergic Fungal Sinusitis

Condition Hierarchy (Ancestors)

Mycoses; Bacterial Infections and Mycoses; Infections; Respiratory Tract Infections; Sinusitis; Paranasal Sinus Diseases; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Central Study Contacts

khater nosir sayed, master

CONTACT

01011973180; khatrsnyr289@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhinosinusitis

Study Record Dates

• First Submitted: April 17, 2024
• First Posted: April 19, 2024
• Study Start: May 1, 2024
• Primary Completion: May 1, 2025
• Study Completion: June 30, 2025
• Last Updated: April 19, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share