Intraoperative Mechanical Power and Ventilation-Associated Lung Injury: Assessing Complications

NCT06375980 | Completed

• 1 other identifier: ANKARA_OR_MP
• Study Type: observational
• Target: 207
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the relationship between intraoperative mechanical power and postoperative pulmonary complications in patients undergoing major abdominal surgery. The investigators record mechanical ventilation parameters and surgical characteristics, assessing the incidence of pulmonary complications within 24 hours postoperatively."

Conditions

Lung Injury; Pulmonary Complication

Keywords

Lung injury; Ventilators, mechanical; Perioperative care; Anesthesia; Risk factors; Ventilator-Induced Lung Injury

Outcome Measures

Primary Outcomes (1)

• Relationship between mechanical power and postoperative pulmonary complications

  This study aimed to assess the association between mechanical power and postoperative pulmonary complications. Mechanical power is a crucial parameter for predicting the risk of lung injury related to mechanical ventilation. Measurement Tool: Mechanical power calculation based on ventilator parameters. Unit of Measure: Mechanical power expressed in joules per minute (J/min).

  Patients were followed for 24 hours postoperatively to evaluate the occurrence of pulmonary complications.

Study Arms (2)

patients who developed postoperative pulmonary complications

This cohort consists of patients who developed postoperative pulmonary complications (PPCs). The cohort of patients developing PPCs includes individuals who experienced postoperative hypoxia, atelectasis, bronchospasm, pulmonary infection, pulmonary infiltration, aspiration pneumonia, acute respiratory distress syndrome, pleural effusion, and pulmonary edema. PPCs were assessed using the European Perioperative Clinical Outcome framework.

Other: Intraoperative Mechanical Ventilation Strategies

patients who did not develop postoperative pulmonary complications .

This cohort comprises patients who did not develop postoperative pulmonary complications (PPCs). The cohort of patients not developing PPCs includes individuals who did not exhibit significant pulmonary complications postoperatively.

Other: Intraoperative Mechanical Ventilation Strategies

Interventions

Intraoperative Mechanical Ventilation Strategies OTHER

The intervention involves the management of mechanical ventilation during major abdominal surgery. This includes the adjustment of ventilation parameters such as tidal volume, respiratory rate, peak pressure, positive end-expiratory pressure (PEEP), and inspiratory flow rate. The aim is to optimize ventilation strategies to reduce the risk of postoperative pulmonary complications

patients who developed postoperative pulmonary complications; patients who did not develop postoperative pulmonary complications .

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of adult patients (aged 18 years and older) scheduled for elective major abdominal surgery.

You may qualify if:

• Patients aged 18 years and older
• Patients undergoing elective major abdominal surgery
• Patients with ASA (American Society of Anesthesiologists) physical status classification I-IV
• Patients capable of providing voluntary consent

You may not qualify if:

• Patients under 18 years of age
• Pregnant individuals
• Those who decline to participate in the study
• Patients requiring reoperation due to surgical complications
• Organ transplant recipients
• Patients who were intubated preoperatively
• Day surgery patients

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Ankara Oncology Training and Research Hospital

Ankara, 06200, Turkey (Türkiye)

Location

Related Publications (5)

• Patel K, Hadian F, Ali A, Broadley G, Evans K, Horder C, Johnstone M, Langlands F, Matthews J, Narayan P, Rallon P, Roberts C, Shah S, Vohra R. Postoperative pulmonary complications following major elective abdominal surgery: a cohort study. Perioper Med (Lond). 2016 May 23;5:10. doi: 10.1186/s13741-016-0037-0. eCollection 2016.

  PMID: 27222707 BACKGROUND

• Khan NA, Quan H, Bugar JM, Lemaire JB, Brant R, Ghali WA. Association of postoperative complications with hospital costs and length of stay in a tertiary care center. J Gen Intern Med. 2006 Feb;21(2):177-80. doi: 10.1111/j.1525-1497.2006.00319.x.

  PMID: 16606377 BACKGROUND

• Miskovic A, Lumb AB. Postoperative pulmonary complications. Br J Anaesth. 2017 Mar 1;118(3):317-334. doi: 10.1093/bja/aex002.

  PMID: 28186222 BACKGROUND

• Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A, Hoeft A, Walder B, Chew MS, Pearse RM; European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM); European Society of Anaesthesiology; European Society of Intensive Care Medicine. Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol. 2015 Feb;32(2):88-105. doi: 10.1097/EJA.0000000000000118.

  PMID: 25058504 BACKGROUND

• Senturk E, Ugur S, Celik Y, Cukurova Z, Asar S, Cakar N. The power of mechanical ventilation may predict mortality in critically ill patients. Minerva Anestesiol. 2023 Jul-Aug;89(7-8):663-670. doi: 10.23736/S0375-9393.23.17080-5. Epub 2023 Apr 20.

  PMID: 37079284 BACKGROUND

MeSH Terms

Conditions

Lung Injury; Ventilator-Induced Lung Injury

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Thoracic Injuries; Wounds and Injuries

Study Officials

• Arif Timuroğlu

  ankara oncology trainig and research hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lead Researcher

Study Record Dates

• First Submitted: April 17, 2024
• First Posted: April 19, 2024
• Study Start: April 1, 2022
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: July 30, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)