Examination of the Relationship Between Weight Gain During Pregnancy and Sfrp-5, Netrin-4 and Resistin Concentrations

NCT06371781 | Completed DMC

• 2 other identifiers: Cumhuriyetobgyn1919B012108892
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Researchers thought that the molecules Sfrp-5, Resistin and Netrin-4, which will be examine, they may have a significant effect on weight gain during pregnancy. Based on these foundations, researchers expect changes in the levels of these molecules in women who gain excessive weight during pregnancy. In this study, researchers aimed to examine the moderator relationship between the molecules will be examine and weight gain in women who gained weight above the normal limits determined during pregnancy. For this reason, 44 participant who gained excessive weight during pregnancy and 46 pregnant participant who gained normal weight were included in the study. The levels of Netrin-4, Sfrp-5 and Resistin molecules in the blood serum of the individuals in the study group were measured with a Commercial Elisa kit.

Conditions

Excessive Weight Gain During Pregnancy

Keywords

Sfrp-5; Netrin-4; Resistin; gestational weight gain

Outcome Measures

Primary Outcomes (1)

• Obtaining blood serum for measurement of serum Sfrp-5, Netrin-4 and Resistin

  Blood will be taken from individuals only once; therefore, minor redness and swelling may occur at the site where blood is taken; other than that, there is no serious risk. The measured molecules will be measured in blood serum and there will be no intervention other than blood collection from individuals.Measurements of these three molecules will be measured simultaneously in a single blood sample.

  one day

Secondary Outcomes (1)

• Calculating BMI (kg/m^2) from height (m) and weight (kg) measurement values for diagnosis.

  one day

Study Arms (2)

Serum Netrin-4, Resistin and Sfrp-5 level measurement

EXPERIMENTAL

In this study, 5 ml of whole blood will be collected from the study group into a biochemistry tube and centrifuged, and the levels of Netrin-4, Resistin and Sfrp-5 in the separated serum will be measured with an ELISA kit.

Diagnostic Test: Serum Netrin-4, Resistin and Sfrp-5 level measurement

diagnosis of the study group

NO INTERVENTION

Individuals who gained excessive weight during pregnancy will be diagnosed as a patient group by evaluating their pre- and post-pregnancy height, weight and BMI values. Those with normal height, weight and BMI values before and after pregnancy will be included in the control group.

Interventions

Serum Netrin-4, Resistin and Sfrp-5 level measurement DIAGNOSTIC_TEST

Measurements of the levels of these molecules in the serum samples of the study group will be done with the ELISA kit.

Serum Netrin-4, Resistin and Sfrp-5 level measurement

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• singleton pregnant women over 37 weeks
• Without metabolic disorders
• Do not use medication
• Healthy fetuses and mom

You may not qualify if:

• pregestational diabetes,
• gestational diabetes
• hypertension and related metabolic diseases
• twin pregnancies,
• pregnancies under 37 weeks
• with large babies

Sponsors & Collaborators

• Cumhuriyet University: lead
• The Scientific and Technological Research Council of Turkey: collaborator

Study Sites (1)

Sivas Cumhuriyet University

Sivas, Centre, 58140, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Gestational Weight Gain

Condition Hierarchy (Ancestors)

Weight Gain; Body Weight Changes; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• İlkin Seda CAN ÇAĞLAYAN, Asso.Prof.

  Cumhuriyet University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Model Details: Pregnant women who were given birth at Cumhuriyet University Faculty of Medicine Hospital Gynecology and Obstetrics Clinic between July 1, 2021 and July 1, 2022 and whose pregnancy follow-ups were performed in our hospital will be included in our prospectively designed study. Researchers will divide the study into two main groups. The first group will consist of pregnant women with above-normal weight gain during pregnancy, and the other group will consist of pregnant women with normal weight gain during pregnancy. It is estimated that 46 control and 44 pregnant women with overweight will be reached during this period. In the study, first a form containing demographic data such as age, education, height and weight will be filled out.

Study Record Dates

• First Submitted: April 4, 2024
• First Posted: April 17, 2024
• Study Start: July 1, 2022
• Primary Completion: July 1, 2022
• Study Completion: July 1, 2023
• Last Updated: April 22, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)