Investigation of the Detection Rate of Pathogenic Viruses in the Feces of Individuals With Non-gastrointestinal Infections

NCT06367647 | Recruiting

• 1 other identifier: zhujiangjy-20240229
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

This project is a cross-sectional study. Investigators plan to search and collect 1600 publicly published fecal metagenomic and metatranscriptome data through the Pubmed database, by summarizing and analyzing them to construct an enterovirus database. 200 apparently healthy individuals are planned to be enrolled. At the time of enrollment, fecal specimens of participants will be collected, and their demographic characteristics, disease and medication history, gastrointestinal status, dietary habits, lifestyle habits, and mental health information will be recorded. Another 200 specimens will be collected from patients with parenteral virus infection. The demographic characteristics and pathogen test results of the parenteral virus infected patients will be reviewed and recorded. By virus metagenomic sequencing on fecal specimens, investigators will identify which viruses can be detected in the intestinal tract of apparently healthy people, and to explore whether parenteral infection viruses can be detected in feces.

Conditions

Virus Infections

Outcome Measures

Primary Outcomes (1)

• virus infection checklist

  Viral infections in the respiratory system, digestive system, urinary system, cardiovascular system, etc.

  2024.3-2025.12

Secondary Outcomes (5)

• general information of apparently healthy individuals by questionnaire

  2024.3-2025.12

• Self-Rating Anxiety Scale SAS

  2024.3-2025.12

• Self-rating depression scale SDS

  2024.3-2025.12

• Pittsburgh sleep quality index PSQI

  2024.3-2025.12

• demographic characteristics case information of parenteral virus infected patients

  2024.3-2025.12

Study Arms (2)

apparently healthy individuals

parenteral virus infected patients

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Apparent healthy people are those who do not have clinically obvious symptoms and signs, but may have underlying health problems or premorbid conditions.

You may qualify if:

• age ranged from 18 to 75 years;
• no obvious symptoms and signs of the disease;
• not taking a drug for a long time;
• good psychological condition ;
• no unhealthy lifestyle;
• willing to participate in the study, sign the informed consent, fill out the questionnaire and provide fecal samples.

You may not qualify if:

• pregnant and lactating women;
• suffering from certain diseases, such as cardiovascular disease, digestive system disease and nervous system disease.

Sponsors & Collaborators

• Zhujiang Hospital: lead

Study Sites (1)

Zhujiang hospital of southern medical university

Guangzhou, Guangdong, 510280, China

RECRUITING

MeSH Terms

Conditions

Virus Diseases

Condition Hierarchy (Ancestors)

Infections

Study Officials

• Yan He, Doctor

  Southern Medical University, China

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yumei Liu, master

CONTACT

+8618810795365; liuyumei1007@163.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 11, 2024
• First Posted: April 16, 2024
• Study Start: May 4, 2024
• Primary Completion: October 31, 2025
• Study Completion: December 31, 2025
• Last Updated: June 24, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)