Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room

NCT06362525 | Recruiting

• 1 other identifier: 2022-389
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who survived a critical condition and who meet at least one of these criteria during their stay in the resuscitation room: (1) deep sedation, (2) intubation, (3) cardiopulmonary resuscitation, or (4) (non-drug-induced) Glasgow Coma Scale score = 3. We also investigate the potential (neuro)physiological markers and biomarkers. In order to help determine the potential risk factors of such episodes, cognitive factors such as dissociative propensity are also investigated. Unexpected visual and auditory stimuli will be displayed. In addition, we assess the evolution of memory, as well as short- and long-term consequences on quality of life, anxiety, and attitudes towards care. Memory of patients who did not meet the above-mentioned criteria are also investigated. A group of 15 healthy participants will be invited to test the stimuli display. Finally, (neuro)physiological parameters of a subsample of dying patients are also investigated.

Conditions

Critical Illness; Near-Death Experience; Consciousness, Loss of; Quality of Life; Emergencies

Keywords

Dream

Outcome Measures

Primary Outcomes (2)

• Detection of potential episodes of disconnected consciousness

  near-death experience (using the Near-Death Experience Content scale); dream

  upon awakening/discharge from the resuscitation room (max 21 days after the admission in the room)

• Detection of potential episodes of connected consciousness

  explicit recall of environmental/external stimuli upon awakening

  upon awakening/discharge from the resuscitation room (max 21 days after the admission in the room)

Secondary Outcomes (4)

• Risk factors

  in the resusctiation room admission

• Quality of life assessment

  at 6-month

• Memory content and evolution assessment

  at 1-month

• Detection of post-traumatic stress disorder (PTSD)

  at 6-month

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult patients admitted in the resuscitation room

You may qualify if:

• patients admitted in the resuscitation room of our university hospital
• French speaking

You may not qualify if:

• Refusal
• Chronic disorder of consciousness
• Deafness
• Blindness
• Dementia
• Hemineglect
• Aphasia

Sponsors & Collaborators

• University of Liege: lead
• Centre Hospitalier Universitaire de Liege: collaborator

Study Sites (1)

CHU of Liège

Liège, 4000, Belgium

RECRUITING

MeSH Terms

Conditions

Critical Illness; Death; Unconsciousness; Emergencies

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms

Central Study Contacts

Charlotte Martial, PhD

CONTACT

+3243233612; cmartial@uliege.be

Pauline Fritz, Ms

CONTACT

pauline.fritz@uliege.be

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 29, 2023
• First Posted: April 12, 2024
• Study Start: October 9, 2023
• Primary Completion: September 30, 2025
• Study Completion (Estimated): September 30, 2027
• Last Updated: April 12, 2024

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be shared with collaborators for the specified time allocated to each respective project. Whereas, data shared on the database will be anonymized and available indefinitely.
• Access Criteria: A written agreement between the groups (university or research teams)

Locations

BE (1)