The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure

NCT06359977 | Not Yet Recruiting

• 1 other identifier: YB-202442
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Neurocritical patients often face the need for removal of endotracheal tubes. However, despite following the extubation criteria for general critical ill patients, neurocritical patients still exhibit a higher rate of weaning failure, significantly higher than that of general critical ill patients. The extubation criteria for general critical patients emphasize the assessment of lung conditions. However, neurological critical patients often have less severe lung damage, but factors such as consciousness level and coughing ability may significantly influence extubation. Quantitative EEG serves as an objective tool to reflect consciousness level status, while bedside ultrasound can assess respiratory muscle function. Additionally, sputum volume may reflect the condition of lung condition. Therefore, we believe that combination of these three indicators can better predict the success of extubation for neurocritical patients.

Conditions

Weaning Failure

Keywords

Quantitative Electroencephalography; ultrasound

Outcome Measures

Primary Outcomes (4)

• Quantitative EEG indicators

  These indicators including amplitude EEG and the proportion of α，β，δ，θ wave

  2 hours before extubation

• Respiratory muscles thickness in centimeter

  Muscle thickness was evaluated by ultrasound.

  2 hours before extubation

• Respiratory muscles thickening fraction (%)

  Muscle thickening fraction was evaluated by ultrasound. It equals (end-inspiratory thickness - end-expiratory thickness)/end-expiratory thickness × 100%.

  2 hours before extubation

• Sputum volume in milliliter

  The amount of sputum

  24 hours before extubation

Study Arms (1)

Neurocritical Patients requiring weaning

The population in this study focused on neurocritical patients with endotracheal intubation. The data of quantitative EEG, beside ultrasound and sputum volume are all recorded for predicting weaning failure.

Other: Quantitative EEG monitoring and beside ultrasound evaluation

Interventions

Quantitative EEG monitoring and beside ultrasound evaluation OTHER

After successful spontaneous breathing trial, neurocritical patients undergo at least 2 hours of quantitative EEG monitoring before extubation. Additionally, bedside ultrasound assesses the thickness and variability of the diaphragm, intercostal muscles, rectus abdominis, transversus abdominis, and external oblique muscles. The sputum volume for the 24 hours prior to extubation is also recorded. Reintubation within 48 hours after extubation is defined as weaning failure.

Neurocritical Patients requiring weaning

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The population in this study focused on neurocritical patients with endotracheal intubation. The data of quantitative EEG, beside ultrasound and sputum volume are all recorded for predicting weaning failure.

You may qualify if:

• Neurocritical patients with endotracheal intubation;
• Successful spontaneous Breathing Trial;
• The patients meet extubation criteria evaluated by clinical physician

You may not qualify if:

• Patients whose families have opted for cessation of treatment.

Sponsors & Collaborators

• Qingdao University: lead

Related Publications (2)

• Welte TM, Gabriel M, Hopfengartner R, Rampp S, Gollwitzer S, Lang JD, Stritzelberger J, Reindl C, Madzar D, Sprugel MI, Huttner HB, Kuramatsu JB, Schwab S, Hamer HM. Quantitative EEG may predict weaning failure in ventilated patients on the neurological intensive care unit. Sci Rep. 2022 May 4;12(1):7293. doi: 10.1038/s41598-022-11196-7.

  PMID: 35508676 RESULT

• Bosel J. Who Is Safe to Extubate in the Neuroscience Intensive Care Unit? Semin Respir Crit Care Med. 2017 Dec;38(6):830-839. doi: 10.1055/s-0037-1608773. Epub 2017 Dec 20.

  PMID: 29262440 RESULT

Study Officials

• bo yao, Dr.

  The Affiliated Hospital of Qingdao University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

bo yao, Dr.

CONTACT

+8618661800691; icuyaobo@126.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: The department of critical care medicine, Affiliated hospital of Qingdao university

Study Record Dates

• First Submitted: April 2, 2024
• First Posted: April 11, 2024
• Study Start: April 15, 2024
• Primary Completion: April 15, 2025
• Study Completion: May 15, 2025
• Last Updated: April 11, 2024

Record last verified: 2024-04