Comparison of Using Collagen Membrane and A-PRF Using VISTA Technique in Gingival Recession Treatment

NCT06357351 | Active Not Recruiting

• 1 other identifier: VISTA in gingival recession
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

To assess the efficacy of minimally invasive Vestibular Incision Subperiosteal Tunnel Access (VISTA) with collagen membrane and Advanced Platelet-rich Fibrin (A-PRF) in the treatment of multiple buccal gingival recession type 1(RT1) Cairo Classification.

Conditions

Gingival Recession

Outcome Measures

Primary Outcomes (4)

• Measuring the recession width in millimeter

  self-report assessment by using the UNC-15 Periodontal Probe, measured at the level of Cemento-Enamel Junction CEJ.

  baseline, 3 months and 6 months

• Measuring the recession depth in millimeter

  self-report assessment by using the UNC-15 Periodontal Probe, measured from the cemento-enamel junction CEJ to the free gingival junction.

  baseline, 3 months and 6 months

• Measuring the width of keratinized gingiva in millimeter

  self-report assessment by using the UNC-15 Periodontal Probe. measured from the free gingiva margin to the mucogingival junction.

  baseline, 3 months and 6 months

• Mean of root coverage

  was measured by the following formula:. Mean root coverage formula: (pre-operative recession depth - post-operative recession depth)/(pre-operative recession depth ) ×100

  baseline, and 6 months

Secondary Outcomes (4)

• Measuring the probing depth

  baseline, 3 months and 6 months

• Measuring the plaque index

  baseline, 3 months and 6 months

• Measuring the gingival index

  baseline, 3 months and 6 months

• Clinical attachment level

  baseline, 3 months and 6 months

Study Arms (2)

VISTA technique and collagen membrane

EXPERIMENTAL

Participants undergo periodontal surgery using the vestibular incision sub-periosteal tunnel access technique (VISTA) and collagen membrane.

Procedure: vestibular incision sub periosteal tunnel access ( VISTA) technique.

VISTA technique and advanced platelet rich fibrin

EXPERIMENTAL

Participants undergo periodontal surgery using the vestibular incision sub-periosteal tunnel access technique (VISTA) and advanced platelet-rich fibrin (A-PRF).

Procedure: vestibular incision sub periosteal tunnel access ( VISTA) technique.

Interventions

vestibular incision sub periosteal tunnel access ( VISTA) technique. PROCEDURE

In comparison between the two groups, the first group uses collagen membrane and the other group uses advanced PRF using the same surgical technique (VISTA)

VISTA technique and advanced platelet rich fibrin; VISTA technique and collagen membrane

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• (18-50) years old with at least 2 sites with gingival recession type (RT1) Cairo Classification (GR with no interdental attachment loss). The interdental CEJ is not detectable clinically on the labial surfaces of the teeth.
• Recession in the maxillary anterior region ≥1 mm of attached gingiva, pocket depth (PD) of \<3 mm, recession depth (RD) ≥2 mm, and gingival index (GI) score ≤1.
• Systemically healthy, willing individuals with good oral hygiene and without contraindications for surgical interventions

You may not qualify if:

• the presence of severe systematic diseases or immunodeficiency and contraindicated with surgical interventions.
• Allergies to medicaments used in the treatment process.
• Patients with removable or fixed dentures.
• Patients with cervical abrasion, direct and indirect restorations involving the cervical areas of the maxillary anterior.
• Participants with smoking, tobacco chewing, and alcohol consumption.
• The presence of high frenal attachment and participants who had previously undergone any periodontal surgical procedure or regenerative therapy in the past 1 year at the same site of the planned treatment.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura university

Al Mansurah, Egypt

Location

Related Publications (1)

• Abdelhaleem M, Saleh W, Elmeadawy S. Treatment of gingival recession with vestibular incision subperiosteal tunnel access and advanced platelet-rich fibrin. BMC Oral Health. 2025 Jan 14;25(1):63. doi: 10.1186/s12903-024-05398-w.

  PMID: 39806320 DERIVED

MeSH Terms

Conditions

Gingival Recession

Interventions

Methods

Condition Hierarchy (Ancestors)

Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master candidate

Study Record Dates

• First Submitted: April 4, 2024
• First Posted: April 10, 2024
• Study Start: July 1, 2022
• Primary Completion: April 1, 2024
• Study Completion: May 1, 2024
• Last Updated: April 10, 2024

Record last verified: 2024-04

Locations

EG (1)