Cycling and Treadmill With Dual Task for Parkinson's Disease Improvement

NCT06355947 | Completed DMC

• 1 other identifier: 103-7445B
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Motor impairment in lower extremities is common in individuals with Parkinson disease (PD). Development sensitive test for early motor deviations is important. Conventional walking test cannot induce the PD related motor impairments, such as freezing of gait. Therefore, finding a safe substitute test to induce PD related motor impairments is important. Studies showed that working memory related dual task walking was a sensitive test for PD. However, the optimal cognitive test needs to be clarified. Studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking. Therefore, dual task cycling test is potential to be a safe and sensitive testing model. Studies showed that exercise could improve cognitive function and induce brain plasticity. Dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall. Whether the added cognitive task could improve to detriment brain plasticity in PD should be investigated. Transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity. The purpose of this three-year project is to develop PD-sensitive. The purposes of the first year are to translate the dual task walking test to dual task cycling test, and to establish the reliability of the dual task cycling test. The purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between PD and healthy control people. The purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with PD on motor cortex plasticity, dual task performance, and ambulation ability.

Conditions

Parkinson Disease(PD)

Keywords

Gait; Cycling training; Treadmill training; Dual-task walking; Dual-task cycling

Outcome Measures

Primary Outcomes (7)

• Walking Speed

  The time taken by participants to walk a standardized distance, typically expressed in centimeters per second (cm/s).

  Baseline, 4 weeks and 8 weeks

• Step Length

  The linear distance between the two ankles, typically expressed in centimeters(cm).

  Baseline, 4 weeks and 8 weeks

• Step Time

  The duration taken for one complete step, measuring from foot-off of one foot to the next foot-off of the same foot, usually expressed in seconds.

  Baseline, 4 weeks and 8 weeks

• Power Spectral Density (PSD)

  Quantifies the power of EEG signals within specific frequency bands (e.g., delta, theta, alpha, beta, and gamma) over a period.

  Baseline, 4 weeks and 8 weeks.

• Task Accuracy

  The percentage of correct responses or actions made by participants in response to walking or cycling tasks.

  Baseline, 4 weeks and 8 weeks.

• Reaction Time

  The duration between the onset of task start time and the participant's response to it, typically expressed in second (s).

  Baseline, 4 weeks and 8 weeks.

• Balance Performance

  Measured by the duration the stance can be maintained, typically expressed second.

  Baseline, 4 weeks and 8 weeks

Secondary Outcomes (6)

• Double Support Time

  Baseline, 4 weeks and 8 weeks

• Single Support Time

  Baseline, 4 weeks and 8 weeks

• Swing Time

  Baseline, 4 weeks and 8 weeks

• Stance Time

  Baseline, 4 weeks and 8 weeks

• Cadence

  Baseline, 4 weeks and 8 weeks

Study Arms (5)

Stage 1:Healthy people

NO INTERVENTION

To establish a baseline and ensure reliability, and to explore the relationship between dual-task gait performance and dual-task cycling

No Intervention: Stage 2:PD people

NO INTERVENTION

To explore the relationship between dual-task gait and dual-task cycling performances in individuals with Parkinson's Disease (PD)

Stage 3:PD cycling training group

EXPERIMENTAL

Cycling training conducted with cognitive tasks

Other: Cognitive cycling training

Stage 3: PD treadmill training group

EXPERIMENTAL

Treadmill training conducted with cognitive tasks

Other: Cognitive treadmill training

Stage 3:PD Control group

NO INTERVENTION

Control group

Interventions

Cognitive cycling training OTHER

Cycling training conducted with cognitive tasks

Stage 3:PD cycling training group

Cognitive treadmill training OTHER

Treadmill training conducted with cognitive tasks

Stage 3: PD treadmill training group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Musculoskeletal injuries on legs.
• Osteoporosis.
• PD subjects:
• \- Clinical diagnosis of Parkinson disease.
• Musculoskeletal injuries on legs
• Osteoporosis.
• Any peripheral or central nervous system injury or disease patients.

Sponsors & Collaborators

• Chang Gung University: lead

Study Sites (1)

Chang Gung University

Taoyuan District, 333, Taiwan

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 26, 2024
• First Posted: April 10, 2024
• Study Start: December 7, 2015
• Primary Completion: September 11, 2017
• Study Completion: July 31, 2018
• Last Updated: April 10, 2024

Record last verified: 2024-04

Locations

TW (1)