The Impact of Diaphragmatic Breathing Instructions and Inspiratory Pressures on Diaphragm Contraction in Healthy Adults

NCT06347549 | Completed DMC

• 1 other identifier: HE-SF2024/09
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

This is a cross-sectional obsessional study. This study aims (1) to investigate the relationship between sternocleidomastoid muscle recruitment and diaphragm thickness fraction during increasing inspiratory resistance in healthy adults; (2) to compare diaphragmatic and sternocleidomastoid muscle recruitment patterns with and without a standard diaphragmatic breathing instruction with increasing inspiratory resistance in healthy adults. Participants will be asked to breathe through a pressure threshold inspiratory loading device under different inspiratory resistances with and without a standard diaphragmatic breathing instruction. sternocleidomastoid muscle activity will be measured with surface electromyography, and diaphragm thickness will be assessed with ultrasonography.

Conditions

Diaphragm

Keywords

Diaphragmatic thickening fraction; Sternocleidomastoid muscles; Inspiratory pressures

Outcome Measures

Primary Outcomes (1)

• Diaphragmatic thickening fraction

  Diaphragmatic thickening fraction is determined by "(thickness of the diaphragm at end inspiratory - thickness at end expiratory)/thickness at end expiratory". Diaphragmatic thickness will be measured by ultrasonography.

  Through study completion, an average of 1 year

Secondary Outcomes (2)

• Muscle activation of the sternocleidomastoid muscle

  Through study completion, an average of 1 year

• Perceived Exertion Borg scale

  Through study completion, an average of 1 year

Study Arms (1)

Healthy adults

Participants ≥18 years of age with normal health will be recruited in this study.

Diagnostic Test: Various intensities of inspiratory muscle training

Interventions

Various intensities of inspiratory muscle training DIAGNOSTIC_TEST

Each participant will be instructed to use a pressure threshold inspiratory loading device to perform, in random order, 10 breaths at an inspiratory intensity of 30%, 40%, 50%, 60%, 70%, and 80% of their maximum inspiratory pressure (MIP). A rest period of 15 minutes will be allowed between each inspiratory pressure set of 10 breaths. Simultaneous surface electromyographic (sEMG) recording of the right sternocleidomastoid muscle and ultrasound of right diaphragmatic thickness will be conducted during each breath. The entire recording procedure will be repeated on a separate day. During the repeat measurements, participants will be provided with specific breathing instruction to focus on the use of the diaphragm and to inhale air to the lower part of the chest.

Healthy adults

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy adults

You may qualify if:

• Participants ≥18 years of age with normal health

You may not qualify if:

• Pregnancy.
• Participants with known cardiovascular, pulmonary, musculoskeletal or psychiatric disorders.
• Participants with respiratory symptoms (from flu or other respiratory infection during the 2 weeks prior to measurements.
• Participants can not cooperate the maximal inspiratory pressure measurement.

Sponsors & Collaborators

• Hong Kong Metropolitan University: lead

Study Sites (1)

Hong Kong Metropolitan University

Hong Kong, None Selected, China

Location

Study Officials

• William Tsang

  Hong Kong Metropolitan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student

Study Record Dates

• First Submitted: March 28, 2024
• First Posted: April 4, 2024
• Study Start: April 8, 2024
• Primary Completion: July 16, 2024
• Study Completion: July 16, 2024
• Last Updated: January 28, 2025

Record last verified: 2025-01

Locations

CN (1)