The Transplant Cohort of the German Center for Infection Research

NCT06346665 | Recruiting

• 1 other identifier: DZIF Tx-Cohort
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

Medical data and biological samples obtained from transplant patients are collected and managed across Germany with the help of the DZIF Transplant Cohort. The data and samples form the basis of scientific studies which investigate the connections between numerous factors influencing an organ's susceptibility to infection and organ function.

Conditions

Infections; Transplant Complication; Transplant Failure; Immunosuppression

Outcome Measures

Primary Outcomes (1)

• Realisation of studies that focus on the the medical needs of transplant patients, particularly with regard to their susceptibility to infection

  Provision of collected data and biosamples to research groups for the realisation of scientific studies with a number of resources that individual clinics could not provide on their own

  10 years

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of any age who have received a kidney, pancreas, liver, heart or stem cell transplant at one of the listed partner centres

You may qualify if:

• Consent
• undergone transplantation of kidney, pancreas, liver, heart or stem cells

You may not qualify if:

• No consent

Sponsors & Collaborators

• Technical University of Munich: lead
• Hannover Medical School: collaborator
• University Hospital Heidelberg: collaborator
• Universität Tübingen: collaborator
• Klinikum der Universität München: collaborator
• Max von Pettenkofer-Institut München: collaborator
• Nierenzentrum Heidelberg: collaborator
• Helmholtz Centre for Infection Research: collaborator

Study Sites (1)

Technische Universität München

München, Germany

RECRUITING

Related Publications (2)

• Karch A, Schindler D, Kuhn-Steven A, Blaser R, Kuhn KA, Sandmann L, Sommerer C, Guba M, Heemann U, Strohaker J, Glockner S, Mikolajczyk R, Busch DH, Schulz TF; for the Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium. The transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics. Eur J Epidemiol. 2021 Feb;36(2):233-241. doi: 10.1007/s10654-020-00715-3. Epub 2021 Jan 25.

  PMID: 33492549 RESULT

• Sommerer C, Schroter I, Gruneberg K, Schindler D, Behnisch R, Morath C, Renders L, Heemann U, Schnitzler P, Melk A, Della Penna A, Nadalin S, Heeg K, Meuer S, Zeier M, Giese T; Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium. Incidences of Infectious Events in a Renal Transplant Cohort of the German Center of Infectious Diseases (DZIF). Open Forum Infect Dis. 2022 May 13;9(7):ofac243. doi: 10.1093/ofid/ofac243. eCollection 2022 Jul.

  PMID: 35855001 RESULT

Related Links

• Transplant Cohort Website of the DZIF

Biospecimen

Retention: SAMPLES WITH DNA

Blood (Serum, plasma, RNA-stabilized, purified PBMC, buffy coat) Stool Urine Buccal swabs

MeSH Terms

Conditions

Infections

Central Study Contacts

Daniela Schindler, Dr.

CONTACT

daniela.schindler@tum.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 26, 2024
• First Posted: April 4, 2024
• Study Start: January 1, 2016
• Primary Completion: December 1, 2025
• Study Completion (Estimated): December 1, 2030
• Last Updated: April 23, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: The use of resources is possible after successful review of the preliminary and main application to the transplant cohort by the internal Scientific Steering Committee and - depending on the study design - external reviewers

Locations

DE (1)