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Outcome Measures

Primary Outcomes (2)

best corrected visual acuity
The best corrected visual acuity of patients at 1 week, 1 month, 3 months and 6 months after surgery
1 week, 1 month, 3 months, 6 months
Central retinal thickness
Central retinal thickness at 1 week, 1 month, 3 months, and 6 months after surgery
1 week, 1 month, 3 months, 6 months

Study Arms (2)

targeted retinal photocoagulation(TRP)

EXPERIMENTAL

TRP is a laser technology aimed at the peripheral non-perfusion and ischemic areas of the retina, and the laser area is determined according to the degree and progression ofthe patient's retinopathy.TRP can speciﬁcally act on unperfused retinal capillaries and retinal intermediate ischemic areas, reduce damage to tissue perfusion areas and panretinal photocoagulation (PRP) complications or adverse events.

Procedure: Intraoperative Fluorescein Angiography

panretinal photocoagulation(PRP)

EXPERIMENTAL

The scope oftraditional PRP is mainly distributed in the middle and peripheral part of the retina, 1.5-2 optic disc diameters (DD) posteriorly from the optic disc and 2 DD temporally from the fovea,bounded by the superior and inferior vascular arches; forward to the ampulla of the vortex vein (or equator). Currently, PRP is the gold standard for the treatment of extensive areas of non-perfusion , as well as the main method for the treatment of severe nonproliferative diabetic retinopathy (NPDR) and PDR. However, due to the photochemical damage of the laser,panretinal laser photocoagulation causes more damage to the ocular tissue, and its side effects include hemorrhage, choroidal detachment, acute angle-closure glaucoma, etc. The occurrence of these complications is closely related to laser parameters such as increased duration and power and intensive treatment in a single session, which all lead to increased diffusion of thermal energy within the retina and choroid .

Interventions

Intraoperative Fluorescein AngiographyProcedure

Targeted laser photocoagulation under the guidance of intraoperative fluoroscopy

panretinal photocoagulation(PRP)targeted retinal photocoagulation(TRP)

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MeSH Terms

Conditions

Diabetic RetinopathyRetinal Vein OcclusionRetinal VasculitisVitreous Hemorrhage

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System DiseasesVenous ThrombosisThrombosisEmbolism and Thrombosis

Study Design

Study Type

interventional

Phase

not applicable

Allocation

RANDOMIZED

Masking

SINGLE

Who Masked

PARTICIPANT

Purpose

TREATMENT

Intervention Model

PARALLEL

Model Details: A total of 80 patients with vitreous hemorrhage diagnosed in Sichuan Provincial People's Hospital from January 2024 to December 2025 were selected. The number of included cases was calculated according to the minimum sample size of 200 patients with vitreous hemorrhage in our hospital, 95% confidence level and 5% confidence interval, and the calculated result was 79. The included cases were equally divided by random number method. 40 patients in the control group were given vitrectomy and other conventional operations such as retinal laser photocoagulation. In contrast group, 40 patients were given vitrectomy combined with intraoperative fluorescein angiography and other conventional operations such as retinal laser photocoagulation. The diagnosis rate of primary disease cause, observation rate of neovascularization and non-perfusion area, visual acuity, visual field, thickness of macular fovea and postoperative complications (ciliary detachment, secondary vitreous hemorrhage, neovascu

Sponsor Type

OTHER

Responsible Party

SPONSOR INVESTIGATOR

PI Title

Principal Investigator

Intraoperative Application of Fluorescein Sodium Angiography in Vascular Retinopathy

Brief Summary

Registry Overview

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First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (2)

targeted retinal photocoagulation(TRP)

panretinal photocoagulation(PRP)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Central Study Contacts

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Source record

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (2)

targeted retinal photocoagulation(TRP)

panretinal photocoagulation(PRP)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record