Neohepatic Albumin-Bilirubin Scores on Renal Outcomes in Living-donor Liver Transplantation Recipients

NCT06340607 | Completed

• 1 other identifier: 2023-0561
• Study Type: observational
• Target: 3,422
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.

Conditions

Acute Kidney Injury; Chronic Kidney Diseases; Graft Failure

Outcome Measures

Primary Outcomes (1)

• acute kidney injury

  determined by change in sCr according to the Kidney Disease: Improving Global Outcomes (KDIGO) definition (increase in sCr of ≥26.5 mmol litre-1 within 48h or ≥1.5 times baseline within 7 days after surgery

  within 7 days after surgery

Secondary Outcomes (2)

• chronic kidney injury

  within 1 year after surgery

• graft failure

  the graft failure at overall period (calculated from the date of surgery to the last follow-up) from the date of surgery (up to 10 years)]

Study Arms (2)

Recipients with neohepatic ALBI ≥ -1.615

The ALBI score was calculated using the formula: (log10bilirubin × 0.66) + (albumin × -0.085), where bilirubin is measured in μmol/L and albumin in g/L. Recipients with neohepatic (post-reperfusion) ALBI ≥ -1.615

Recipients with neohepatic ALBI < -1.615

Recipients with neohepatic (post-reperfusion) ALBI \< -1.615

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

living donor liver transplantation recipients at Asan Medical Center, Seoul, Korea from January 2012 to December 2019

You may qualify if:

• living donor liver transplantation recipients (≥18 years)

You may not qualify if:

• preoperative serum creatinine (sCr) \> 1.4 mg/dL, diagnosed CKD or hepatorenal syndrome (HRS), or hemodialysis at baseline

Sponsors & Collaborators

• Asan Medical Center: lead

Study Sites (1)

Asan Medical Center

Seoul, Song-pa Gu, 05500, South Korea

Location

MeSH Terms

Conditions

Acute Kidney Injury; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 25, 2024
• First Posted: April 1, 2024
• Study Start: January 5, 2012
• Primary Completion: January 5, 2020
• Study Completion: December 31, 2022
• Last Updated: April 1, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)