Postoperative New-onset Proteinuria and Adverse Outcomes.

NCT06339229 | Completed

• 1 other identifier: FSYYY-2024-12
• Study Type: observational
• Target: 2,983,899
• Locations: 0 countries
• Sites: N/A

Brief Summary

We aimed to assess the association between postoperative new-onset proteinuria, all-cause mortality, and decline in kidney function in Chinese people who underwent surgery. The exposure variable was the dipstick proteinuria values from the initial postoperative urinalysis within 30 days after surgery, categorized as negative, trace, 1+, and ≥2+. The primary outcome was 30-day mortality. The secondary outcomes included 1-year mortality and composite kidney outcome assessed using the postoperative estimated glomerular filtration rate.

Conditions

Surgery; Proteinuria; Mortality

Outcome Measures

Primary Outcomes (1)

• mortality

  30-day

Study Arms (1)

surgery patients

Other: proteinuria

Interventions

proteinuria OTHER

dipstick proteinuria values negative, trace, 1+, and ≥2+

surgery patients

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes, participants aged ≥16 years who underwent surgery from January 2000 to December 2022 were included.

You may qualify if:

• surgery patients

You may not qualify if:

• kidney or urinary surgery
• missing urinalysis results
• dipstick proteinuria indicated a value of "≥ trace" at least once preoperatively
• with dialysis, end-stage renal disease, or with urinary tract infection at baseline
• missing follow-up information

Sponsors & Collaborators

• Yaozhong Kong: lead

MeSH Terms

Conditions

Proteinuria

Condition Hierarchy (Ancestors)

Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 25, 2024
• First Posted: April 1, 2024
• Study Start: January 1, 2000
• Primary Completion: December 31, 2022
• Study Completion: November 1, 2023
• Last Updated: April 1, 2024

Record last verified: 2024-03