Relationship Between Breathing and Attention in Children With Ondine Syndrome

NCT06337149 | Recruiting

• 2 other identifiers: APHP230348IDRCB: 2023-A00006-39
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that alters oxygen delivery to the brain. CCHS patients are at risk for broad neurocognitive deficits. Patients retain ventilatory activity when awake through a respiratory-related cortical network but the need to mobilise cortical resources to breathe lead to breathing-cognition interferences during cognitive tasks. The purpose of this study is to assess the relationship between breathing pattern and attention in CCHS children

Conditions

Ondine Syndrome; Congenital Central Hypoventilation Syndrome (CCHS)

Outcome Measures

Primary Outcomes (2)

• Wechsler scale

  Neuropsychological assessement

  12 months

• Nepsy II test

  Neuropsychological assessement

  12 months

Interventions

neuropsychological tests used usually in clinical practice (TEA-ch, NEPSY, BRIEF) and research (Conners 3, K-CPT II or CPT III, Flankers Task) OTHER

neuropsychological tests used usually in clinical practice (TEA-ch, NEPSY, BRIEF) and research (Conners 3, K-CPT II or CPT III, Flankers Task)

Eligibility Criteria

• Age: 6 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Ondine Syndrome, children with CCHS

You may qualify if:

• children with CCHS (Ondine Syndrome) and IQ \> 70, age from 6 to 16 years old, french speaking, informed consent signed by both parents and oral agreement in principle given by the subject.

You may not qualify if:

• IQ \< 70

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Robert Debre Hospital

Paris, 75019, France

RECRUITING

MeSH Terms

Conditions

Sleep Apnea, Central; Congenital central hypoventilation syndrome

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Anne-Claude TABET, MD, PhD

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christophe DELCLAUX, MD, PhD

CONTACT

+331 40 03 41 90; christophe.delclaux@aphp.fr

Benjamin DUDOIGNON, MD

CONTACT

+331 40 03 41 90; benjamin.dudoignon@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2024
• First Posted: March 29, 2024
• Study Start: February 29, 2024
• Primary Completion: March 1, 2025
• Study Completion (Estimated): September 1, 2026
• Last Updated: March 29, 2024

Record last verified: 2024-03

Locations

FR (1)