Cord Blood Alarin Levels in Term Babies

NCT06333548 | Completed DMC

• 1 other identifier: KSH_MB_2024_1
• Study Type: observational
• Target: 87
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, alarin levels in the cord blood of babies with large birth weights will be compared with babies of normal weight. Thus, the investigators aimed to find out whether there is a relationship between babies' birth weights and alarin.

Conditions

Birth Weight

Keywords

NEWBORN; ALARİN; UMBİLİCAL CORD BLOOD

Outcome Measures

Primary Outcomes (1)

• Comparison of cord blood alarin levels of babies in different groups according to birth weight (low-appropriate-large) and babies of mothers diagnosed with gestational diabetes regardless of birth weight.

  umbilical cord blood alarin levels

  postnatal 5 minutes

Study Arms (4)

Appropriate for gestational age

Appropriate for gestational age

Diagnostic Test: Appropriate for gestational age , small for gestational age, large for gestational age, Baby of mother diagnosed with GDM

small for gestational age

small for gestational age

Diagnostic Test: Appropriate for gestational age , small for gestational age, large for gestational age, Baby of mother diagnosed with GDM

large for gestational age

large for gestational age

Diagnostic Test: Appropriate for gestational age , small for gestational age, large for gestational age, Baby of mother diagnosed with GDM

Baby of mother diagnosed with GDM

Baby of mother diagnosed with gestational diabetes mellitus

Diagnostic Test: Appropriate for gestational age , small for gestational age, large for gestational age, Baby of mother diagnosed with GDM

Interventions

Appropriate for gestational age , small for gestational age, large for gestational age, Baby of mother diagnosed with GDM DIAGNOSTIC_TEST

No intervention

Appropriate for gestational age; Baby of mother diagnosed with GDM; large for gestational age; small for gestational age

Eligibility Criteria

• Age: 1 Minute - 5 Minutes
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Babies born between the planned dates and whose families gave consent for the study were divided into four different groups according to their characteristics: 1. Babies with normal weight according to gestational age (AGA): 25 babies were included in the study. 2. Low weight babies for gestational age (SGA): 20 babies were included in the study. 3. Large-weight babies for gestational age (LGA): 22 babies were included in the study. 4. Babies whose mothers had gestational diabetes mellitus: 20 babies were included in the study.

You may qualify if:

• Babies given consent by their families
• Healthy babies

You may not qualify if:

• Babies with syndromic appearance or any accompanying disease
• Babies whose family does not give consent

Sponsors & Collaborators

• Konya City Hospital: lead

Study Sites (1)

MELEK

Konya, Sıhhiye, 06100, Turkey (Türkiye)

Location

Related Publications (2)

• Zhou X, Luo M, Zhou S, Cheng Z, Chen Z, Yu X. Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients. Diabetes Metab Syndr Obes. 2021 Jan 27;14:379-385. doi: 10.2147/DMSO.S290072. eCollection 2021.

  PMID: 33536771 RESULT

• Hu W, Fan X, Zhou B, Li L, Tian B, Fang X, Xu X, Liu H, Yang G, Liu Y. Circulating alarin concentrations are high in patients with type 2 diabetes and increased by glucagon-like peptide-1 receptor agonist treatment: An Consort-compliant study. Medicine (Baltimore). 2019 Jul;98(28):e16428. doi: 10.1097/MD.0000000000016428.

  PMID: 31305464 RESULT

MeSH Terms

Conditions

Birth Weight

Interventions

Gestational Age

Condition Hierarchy (Ancestors)

Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Fetal Development; Embryonic and Fetal Development; Morphogenesis; Growth and Development; Physiological Phenomena; Reproductive Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Study Officials

• MELEK BUYUKEREN

  Konya City Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 20, 2024
• First Posted: March 27, 2024
• Study Start: September 18, 2023
• Primary Completion: December 23, 2023
• Study Completion: January 15, 2024
• Last Updated: March 29, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: 6 months after the article was published
• Access Criteria: The data set generated and analyzed in this study are available from corresponding author on a reasonable request.

Locations

TU (1)