Liwan Eye Study: the Fourth Follow-up

NCT06333470 | Not Yet Recruiting DMC

• 1 other identifier: 2024KYPJ025
• Study Type: observational
• Target: 600
• Locations: 0 countries
• Sites: N/A

Brief Summary

Primary angle-closure glaucoma (PACG) is one of the major causes of blindness affecting more than 20 million patients worldwide. The goals of this observational cohort study are to investigate the 20-year incidence of PACG in Chinese population aged 50 years and to develop prediction models for the long-term risk of progression from primary angle-closure suspect (PACS) to PACG.

Conditions

Primary Angle-Closure Glaucoma

Outcome Measures

Primary Outcomes (1)

• The 20-year incidence of primary angle-closure glaucoma (PACG) in Chinese population aged over 50 years

  The presence of PACG is determined by visual acuity, intraocular pressure, anterior segment optical coherence tomography (AS-OCT). The incidence of PACG is defined as the number of new cases of PACG divided by the number of individuals without PACG at baseline.

  20-year

Secondary Outcomes (2)

• The development of prediction models for the long-term risk of progression from primary angle-closure suspect (PACS) to primary angle-closure glaucoma (PACG)

  5-year, 10-year, 20-year

• The 20-year incidence of visual impairment in Chinese population aged over 50 years

  20-year

Interventions

Primary angle closure diseases OTHER

Primary angle-closure suspect (PACS), which is characterized by appositional angle closure, is the earliest stage of primary angle closure diseases and can finally progress to primary angle-closure glaucoma (PACG).

Eligibility Criteria

• Age: 70 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All participants who will be follow-up in this study are from the Liwan Eye Study. At baseline, study subjects were enrolled in Liwan District, Guangzhou. (Liwan District is 1 of 10 administrative districts in Guangzhou, with a population of 514,600.) The decision to select this district for the survey was taken because of its stable, older population and a socioeconomic profile representative of Guangzhou as a whole. Individuals aged 50 years or more who had been resident in the selected study districts for more than 6 months were considered eligible during the enumeration. A total of 1405 eligible subjects were identified from the register.

You may qualify if:

• Participants who have previously participated in the Liwan Eye Study
• Individuals who sign an informed consent form voluntarily

You may not qualify if:

• None

Sponsors & Collaborators

• Zhongshan Ophthalmic Center, Sun Yat-sen University: lead

Biospecimen

Retention: SAMPLES WITH DNA

Human blood sample

MeSH Terms

Conditions

Glaucoma, Angle-Closure

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Officials

• Wei Wang, PhD

  Zhongshan Ophthalmic Center, Sun Yat-sen University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wei Wang, PhD

CONTACT

(0)20 87334687; wangwei@gzzoc.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2024
• First Posted: March 27, 2024
• Study Start: March 30, 2024
• Primary Completion: September 30, 2024
• Study Completion: September 30, 2024
• Last Updated: March 28, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Access Criteria: For access to the data, please contact the principal investigator after the study is completed.