Physiotherapy and Reaction Time in Hemophilia

NCT06331091 | Completed DMC

• 1 other identifier: YuzuncuYıl2022/2
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

This randomised controlled study was conducted to investigate the comprehensive physiotherapy combined with home exercises on individuals with hemophilic arthropathy in the lower extremity. There are two groups in the study: home exercises and comprehensive physiotherapy combined with home exercises. Is physiotherapy combined with home exercises superior to home exercises on joint health, bleeding frequency, reaction time, dynamic balance, muscle strength? The aim of this study is to increase the compliance of hemophilic individuals to physiotherapy and adapt home exercises to their lives with weekly sessions.

Conditions

Hemophilia Arthropathy

Keywords

hemophilia; physiotherapy; exercise; reaction time; joint health; arthropathy

Outcome Measures

Primary Outcomes (2)

• Hemophilia Joint Health Score

  Joint health (Max values= 84, min values=0. As the value increases, joint health worsens.)

  6 weeks

• Reaction time

  Dynamic balance

  6 week

Study Arms (2)

Home exercise

ACTIVE COMPARATOR

This group performed the same exercises given to comprehensive physiotherapy group at home 3 times a week for 6 weeks.

Other: Home exercise

Comprehensive physiotherapy

EXPERIMENTAL

This group received comprehensive physiotherapy (manual therapy, neuromuscular electrical stimulation and exercises) 1 day a week, and did the exercises at home the other 2 days a week for 6 weeks.

Other: Home exercise; Other: Manual therapy; Device: Neuromuscular electrical stimulation; Other: Supervised exercise

Interventions

Home exercise OTHER

Home exercise are done at home without the supervision of a specialist.

Comprehensive physiotherapy; Home exercise

Manual therapy OTHER

Manual therapy is special techniques for soft tissues and joints applied by a physiotherapist.

Comprehensive physiotherapy

Neuromuscular electrical stimulation DEVICE

Home exercise are done at home without the supervision of a specialist. Manual therapy is special techniques for soft tissues and joints applied by a physiotherapist. Neuromuscular electrical stimulation is the application of electrical current to the muscle through special electrodes in order to increase muscle strength. Supervised exercise is done under the supervision of a physiotherapist.

Comprehensive physiotherapy

Supervised exercise OTHER

Supervised exercise is done under the supervision of a physiotherapist.

Comprehensive physiotherapy

Eligibility Criteria

• Age: 10 Years - 32 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Clinical diagnosis of hemophilic arthropathy in ankle and/or

You may not qualify if:

• Clinical diagnosis of any neurological disease

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Van Yüzüncü Yıl University

Van, 65080, Turkey (Türkiye)

Location

Related Publications (1)

• Tat AM, Tat NM, Sekeroz S, Buke M, Karaman K. Low frequency physiotherapy on joint health, hemarthrosis, walking, balance and reaction time in hemophilic arthropathy: a controlled trial. BMC Musculoskelet Disord. 2025 Apr 4;26(1):332. doi: 10.1186/s12891-025-08549-4.

  PMID: 40186132 DERIVED

MeSH Terms

Conditions

Hemophilia A; Motor Activity; Joint Diseases

Interventions

Musculoskeletal Manipulations

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders, Inherited; Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Coagulation Protein Disorders; Hemorrhagic Disorders; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Behavior; Musculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Officials

• Ayse Merve Tat, Asst. Prof.

  Van Yüzüncü Yıl University, Faculty of Health Science

  STUDY CHAIR

• Necati Muhammed Tat

  Van Yüzüncü Yıl University, Faculty of Health Science

  PRINCIPAL INVESTIGATOR

• Serbay Şekeröz, Asst. Prof.

  Van Yüzüncü Yıl University, Faculty of Health Science

  PRINCIPAL INVESTIGATOR

• Meryem M Büke, Asst. Prof.

  Van Yüzüncü Yıl University, Faculty of Health Science

  PRINCIPAL INVESTIGATOR

• Kamuran M Karaman, Prof.

  Van Yüzüncü Yıl University, Faculty of Medicine

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assisstant Professor

Model Details: Randomised controlled study

Study Record Dates

• First Submitted: March 19, 2024
• First Posted: March 26, 2024
• Study Start: December 10, 2022
• Primary Completion: January 19, 2024
• Study Completion: January 19, 2024
• Last Updated: April 2, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)