NCT06327516

Brief Summary

The study aims to investigate the relationship between the small molecule metabolite lysophosphatidylglycerol and asthma clinical features and explore its involvement in asthma pathogenesis.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
250

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2015

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2015

Completed
9.2 years until next milestone

First Submitted

Initial submission to the registry

March 17, 2024

Completed
8 days until next milestone

First Posted

Study publicly available on registry

March 25, 2024

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2024

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2025

Completed
Last Updated

March 26, 2024

Status Verified

March 1, 2024

Enrollment Period

10 years

First QC Date

March 17, 2024

Last Update Submit

March 24, 2024

Conditions

Asthma

Keywords

asthmalysophosphatidylglycerolTreg

Outcome Measures

Primary Outcomes (1)

  • lipidomics

    collect blood for lipidomic analysis and in vitro assays on Day1

    when enrolled

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with asthma who visited or were hospitalized in the Department of Respiratory and Critical Care Medicine of Peking University Third Hospital, who met the asthma diagnostic criteria proposed in the Bronchial Asthma Prevention and Treatment Guidelines and healthy controls without history or symptoms of chronic respiratory disease, allergic status or other conditions that could affect the outcome.

You may qualify if:

  • \. clinical diagnosis of asthma.

You may not qualify if:

  • Combined with chronic obstructive pulmonary disease, bronchiectasis, pneumonia, obstructive sleep apnea hypopnea syndrome, malignant tumor
  • Combined with acute and chronic respiratory failure
  • Combined with severe cardiovascular disease
  • Pregnant woman.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Peking university third hospital

Beijing, None Selected, 100191, China

RECRUITING

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Chun Chang

    Peking University Third Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Chun Chang

CONTACT

15810075362doudou1977bysy@sina.com

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 17, 2024

First Posted

March 25, 2024

Study Start

January 1, 2015

Primary Completion

December 31, 2024

Study Completion

June 30, 2025

Last Updated

March 26, 2024

Record last verified: 2024-03

Locations

CN(1)