Social Network Overdose Prevention and Education Intervention

NCT06327061 | Recruiting

• 2 other identifiers: IRB00026607R01DA058659
• Study Type: interventional
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs).

Conditions

Drug Overdose

Outcome Measures

Primary Outcomes (2)

• Number of drug overdoses

  Number of drug overdoses in prior three months

  3-months

• Participant drug use

  Proportion of times participants tested positive for drugs of fentanyl and xylazine using test strips in the prior 3 months.

  3-months

Secondary Outcomes (1)

• Number of Network member contacts

  3-months

Study Arms (2)

Experimental: Peer education and network support

EXPERIMENTAL

During sessions 1 and 2, participants will be taught information and skills pertaining to overdose prevention and response. During the 3rd session, participants will trained to talk to their non drug using network members in overdose prevention and response.

Behavioral: Network overdose prevention

comparison: Standard of care of health education

ACTIVE COMPARATOR

In one session, participants will receive the standard of care for overdose prevention.

Behavioral: Standard of care health education

Interventions

Standard of care health education BEHAVIORAL

Participants will receive the standard of care for overdose prevention.

comparison: Standard of care of health education

Network overdose prevention BEHAVIORAL

Participants are taught overdose prevention methods with network members.

Experimental: Peer education and network support

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• self-reported illicit opioid use at least 2 times in the past two weeks;
• age 18 and older;
• living in the Baltimore metropolitan region;
• willing to engage in peer education; and
• having and willing to recruit at least one non-using network member.

You may not qualify if:

• Participants without the cognitive ability to provide informed consent and have the physical ability to participate in in-person intervention sessions.

Sponsors & Collaborators

• Johns Hopkins Bloomberg School of Public Health: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Johns Hopkins Bloomberg School of Public Health

Baltimore, Maryland, 21205, United States

RECRUITING

MeSH Terms

Conditions

Drug Overdose

Condition Hierarchy (Ancestors)

Prescription Drug Misuse; Drug Misuse; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Carl Latkin, PhD

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Carl Latkin, PhD

CONTACT

(410)955-3972; carl.latkin@jhu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Both groups receive overdose prevention training
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: a standard two-group clinical trial, one group is the experimental, the other the control

Study Record Dates

• First Submitted: March 15, 2024
• First Posted: March 25, 2024
• Study Start: June 1, 2024
• Primary Completion (Estimated): April 30, 2028
• Study Completion (Estimated): April 1, 2029
• Last Updated: March 4, 2026

Record last verified: 2026-03

Locations

US (1)