NCT06325436

Brief Summary

To assess the prognostic performance of the ALBI associated scores (ALBI, PALBI and INR-ALBI score) and new MELD .3 in predicting the short-term outcomes (early re-bleeding and early mortality) of patients with cirrhosis presenting with acute variceal bleeding, comparable to the CTP and MELD and MELD Na scores.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
85

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Mar 2024

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2024

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

March 16, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 22, 2024

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2025

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2026

Completed
Last Updated

March 22, 2024

Status Verified

March 1, 2024

Enrollment Period

1.2 years

First QC Date

March 16, 2024

Last Update Submit

March 16, 2024

Conditions

Variceal Hemorrhage

Outcome Measures

Primary Outcomes (1)

  • assess the prognostic performance of the ALBI_associated scores and new MELD .3 in predicting the short-term outcomes of patients with cirrhosis presenting with acute variceal bleeding.

    assess the prognostic performance of the ALBI\_associated scores (ALBI, PALBI and INR-ALBI score) and new MELD .3 in predicting the short-term outcomes (early re-bleeding and early mortality) of patients with cirrhosis presenting with acute variceal bleeding, comparable to the CTP and MELD and MELD Na scores.

    baseline

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Any cirrhotic patients present with variceal bleeding.

You may qualify if:

  • Any cirrhotic patients above the age of 18 years old of both sexes, present with variceal bleeding.

You may not qualify if:

  • Patients with other causes of upper gastrointestinal bleeding (UGIB).
  • Patients who are receiving anticoagulant or antiplatelet therapy.
  • Patients with HCC, other malignant tumors, and hematological disease at the time of recruitment or during follow up.
  • Patients who underwent transjugular intrahepatic portosystemic shunt, splenectomy, or partial splenic embolization.
  • Patients with liver cirrhosis and portal vein thrombosis.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (18)

  • Alqahtani SA, Jang S. Pathophysiology and Management of Variceal Bleeding. Drugs. 2021 Apr;81(6):647-667. doi: 10.1007/s40265-021-01493-2. Epub 2021 Mar 12.

    PMID: 33710585BACKGROUND

  • Drolz A, Ferlitsch A, Fuhrmann V. Management of Coagulopathy during Bleeding and Invasive Procedures in Patients with Liver Failure. Visc Med. 2018 Aug;34(4):254-258. doi: 10.1159/000491106. Epub 2018 Jul 16.

    PMID: 30345282BACKGROUND

  • Reiberger T, Puspok A, Schoder M, Baumann-Durchschein F, Bucsics T, Datz C, Dolak W, Ferlitsch A, Finkenstedt A, Graziadei I, Hametner S, Karnel F, Krones E, Maieron A, Mandorfer M, Peck-Radosavljevic M, Rainer F, Schwabl P, Stadlbauer V, Stauber R, Tilg H, Trauner M, Zoller H, Schofl R, Fickert P. Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III). Wien Klin Wochenschr. 2017 Nov;129(Suppl 3):135-158. doi: 10.1007/s00508-017-1262-3. Epub 2017 Oct 23.

    PMID: 29063233BACKGROUND

  • de Franchis R; Baveno VI Faculty. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015 Sep;63(3):743-52. doi: 10.1016/j.jhep.2015.05.022. Epub 2015 Jun 3. No abstract available.

    PMID: 26047908BACKGROUND

  • Sharara AI, Rockey DC. Gastroesophageal variceal hemorrhage. N Engl J Med. 2001 Aug 30;345(9):669-81. doi: 10.1056/NEJMra003007. No abstract available.

    PMID: 11547722BACKGROUND

  • Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, Yeo W, Mo F, Lai P, Inarrairaegui M, Chan SL, Sangro B, Miksad R, Tada T, Kumada T, Toyoda H. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015 Feb 20;33(6):550-8. doi: 10.1200/JCO.2014.57.9151. Epub 2014 Dec 15.

    PMID: 25512453BACKGROUND

  • Chan AW, Chan RC, Wong GL, Wong VW, Choi PC, Chan HL, To KF. New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score. J Gastroenterol Hepatol. 2015 Sep;30(9):1391-6. doi: 10.1111/jgh.12938.

    PMID: 25753927BACKGROUND

  • Elshaarawy O, Allam N, Abdelsameea E, Gomaa A, Waked I. Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis. World J Hepatol. 2020 Mar 27;12(3):99-107. doi: 10.4254/wjh.v12.i3.99.

    PMID: 32231763BACKGROUND

  • Li F, Wang T, Liang J, Qian B, Tang F, Gao Y, Lv J. Albumin-bilirubin grade and INR for the prediction of esophagogastric variceal rebleeding after endoscopic treatment in cirrhosis. Exp Ther Med. 2023 Sep 11;26(5):501. doi: 10.3892/etm.2023.12200. eCollection 2023 Nov.

    PMID: 37822588BACKGROUND

  • Wang J, Zhang Z, Yan X, Li M, Xia J, Liu Y, Chen Y, Jia B, Zhu L, Zhu C, Huang R, Wu C. Albumin-Bilirubin (ALBI) as an accurate and simple prognostic score for chronic hepatitis B-related liver cirrhosis. Dig Liver Dis. 2019 Aug;51(8):1172-1178. doi: 10.1016/j.dld.2019.01.011. Epub 2019 Jan 26.

    PMID: 30765220BACKGROUND

  • Kim WR, Mannalithara A, Heimbach JK, Kamath PS, Asrani SK, Biggins SW, Wood NL, Gentry SE, Kwong AJ. MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era. Gastroenterology. 2021 Dec;161(6):1887-1895.e4. doi: 10.1053/j.gastro.2021.08.050. Epub 2021 Sep 3.

    PMID: 34481845BACKGROUND

  • Buckholz A, Wong R, Curry MP, Baffy G, Chak E, Rustagi T, Mohanty A, Fortune BE. MELD, MELD 3.0, versus Child score to predict mortality after acute variceal hemorrhage: A multicenter US cohort. Hepatol Commun. 2023 Sep 11;7(10):e0258. doi: 10.1097/HC9.0000000000000258. eCollection 2023 Oct 1.

    PMID: 37695092BACKGROUND

  • Jairath V, Rehal S, Logan R, Kahan B, Hearnshaw S, Stanworth S, Travis S, Murphy M, Palmer K, Burroughs A. Acute variceal haemorrhage in the United Kingdom: patient characteristics, management and outcomes in a nationwide audit. Dig Liver Dis. 2014 May;46(5):419-26. doi: 10.1016/j.dld.2013.12.010. Epub 2014 Jan 14.

    PMID: 24433997BACKGROUND

  • Boregowda U, Umapathy C, Halim N, Desai M, Nanjappa A, Arekapudi S, Theethira T, Wong H, Roytman M, Saligram S. Update on the management of gastrointestinal varices. World J Gastrointest Pharmacol Ther. 2019 Jan 21;10(1):1-21. doi: 10.4292/wjgpt.v10.i1.1.

    PMID: 30697445BACKGROUND

  • Yang H, Pan C, Liu Q, Wang Y, Liu Z, Cao X, Lei J. Correlation between the Glasgow-Blatchford score, shock index, and Forrest classification in patients with peptic ulcer bleeding. Turk J Med Sci. 2020 Jun 23;50(4):706-712. doi: 10.3906/sag-1906-154.

    PMID: 32041384BACKGROUND

  • van Dam GM, Gips CH, Reisman Y, Maas KW, Purmer IM, Huizenga JR, Verbaan BW. Major clinical events, signs and severity assessment scores related to actual survival in patients who died from primary biliary cirrhosis. A long-term historical cohort study. Hepatogastroenterology. 1999 Jan-Feb;46(25):108-15.

    PMID: 10228773BACKGROUND

  • Shetty K, Rybicki L, Carey WD. The Child-Pugh classification as a prognostic indicator for survival in primary sclerosing cholangitis. Hepatology. 1997 May;25(5):1049-53. doi: 10.1002/hep.510250501.

    PMID: 9141416BACKGROUND

  • Zhao Y, Ren M, Lu G, Lu X, Yin Y, Zhang D, Wang X, Ma W, Li Y, Cai G, Lin Y, He S. The Prognosis Analysis of Liver Cirrhosis with Acute Variceal Bleeding and Validation of Current Prognostic Models: A Large Scale Retrospective Cohort Study. Biomed Res Int. 2020 Aug 16;2020:7372868. doi: 10.1155/2020/7372868. eCollection 2020.

    PMID: 32879889BACKGROUND

Central Study Contacts

Rawnaa Hosny Ammar, Resident

CONTACT

+201090155390rawnaahosny@yahoo.com

Nahed Ahmed Makhlouf, Assistant Professor

CONTACT

+201008611626nahedmak@yahoo.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Resident doctor

Study Record Dates

First Submitted

March 16, 2024

First Posted

March 22, 2024

Study Start

March 1, 2024

Primary Completion

May 1, 2025

Study Completion

January 1, 2026

Last Updated

March 22, 2024

Record last verified: 2024-03