Immune Function of Colorectal Cancer Lymph Nodes

NCT06319404 | Not Yet Recruiting

• 1 other identifier: 2022YFC2505700
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.

Conditions

Colorectal Cancer; Lymph Node

Outcome Measures

Primary Outcomes (3)

• To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics

  BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them

  2024.04-2026.04

• To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics

  Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways

  2024.04-2026.04

• The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics

  Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment

  2024.04-2026.04

Study Arms (2)

negative lymph node

postive lymph node

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Stage I-III colorectal cancer patients undergoing radical surgery with complete clinical imaging, pathology, and genetic data.

You may qualify if:

• Stage I-III colorectal cancer patients undergoing radical surgery
• Complete imaging, pathology and genetics multi-omics data available
• years old

You may not qualify if:

• Patients with preoperative neoadjuvant therapy
• Patients with incomplete clinical information
• Patients with other malignant tumors
• Patients with acute infections or untreated chronic infections

Sponsors & Collaborators

• The Second Affiliated Hospital of Harbin Medical University: collaborator
• Shanxi Province Cancer Hospital: lead
• Cancer Institute and Hospital, Chinese Academy of Medical Sciences: collaborator

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Central Study Contacts

Xu Guan

CONTACT

13141307719; drguanxu@163.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 19, 2024
• First Posted: March 20, 2024
• Study Start: April 1, 2024
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: March 20, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share