Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19

NCT06318208 | Completed

• 1 other identifier: C-LCI
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

The study investigates whether patients with mild SARS-CoV-2 infection, who stayed at home during their infection and weren't hospitalized, have any persisting sequelae in pulmonary function. Therefore, 110 patients, aged 6-60 years, were recruited by telephone 4-12 weeks after laboratory-confirmed positive PCR and invited for a lung function testing. Every patient with abnormalities in pulmonary function was invited to a follow-up 3 months after the first appointment to assess changes in lung function values. Patients with a pre-existing lung disease and smokers within the last five years were excluded beforehand. Additionally to lung function testing we did a throat swab at each appointment to analyse via Multiplex PCR whether the patients had any other respiratory infection at the time of the pulmonary function testing.

Conditions

SARS-CoV-2 Infection

Keywords

mild COVID-19; LCI; lung function; non-hospitalized COVID-19

Outcome Measures

Primary Outcomes (1)

• Pulmonary function

  Pulmonary function after SARS-CoV-2 Infection

  4.3 - 11.3 weeks after positive PCR for SARS-CoV-2

Secondary Outcomes (2)

• Changes in pulmonary function

  11.0 - 16.7 weeks after the first lung function testing

• Sociodemographic factors

  9 months

Interventions

lung function testing DIAGNOSTIC_TEST

lung function testing including LCI, FEV1, FVC, DLCO

Eligibility Criteria

• Age: 6 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

SARS-Covid -2 Infection 1 months before investigation

You may qualify if:

• SARS-CoV-2 Infection, non-hospitalized during infection

You may not qualify if:

• Smoking, existing lung disease (COPD, Asthma bronchiale)

Sponsors & Collaborators

• University of Rostock: lead

Study Sites (1)

Kinder- und Jugendklinik Universitätsmedizin Rostock

Rostock, 18057, Germany

Location

Related Publications (1)

• Gorges AR, Warnke P, Lobermann M, Zapf A, Weitzel J, Steinbach ML, Zufle-Lemke N, Fischer DC, Ballmann M. Pulmonary function in non-hospitalized adults and children after mild COVID-19: a single-centre prospective cohort study. BMC Pulm Med. 2025 Nov 6;25(1):511. doi: 10.1186/s12890-025-04007-y.

  PMID: 41199209 DERIVED

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Manfred Ballmann, Prof. Dr.

  UMR Kinder- und Jugendklinik

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 17, 2024
• First Posted: March 19, 2024
• Study Start: April 20, 2021
• Primary Completion: January 3, 2022
• Study Completion: January 3, 2022
• Last Updated: March 26, 2024

Record last verified: 2024-03

Locations

DE (1)