Subendocardial Viability Ratio in Hypertension

NCT06309511 | Recruiting

• 1 other identifier: 09C218
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 5

Brief Summary

The aim of the research is to evaluate the Subendocardial Viability Ratio (SEVR) in hypertensive patients, using non-invasive arterial tonometry, and to establish the influencing factors and the possibility of predicting cardiovascular morbidity and mortality in arterial hypertension. The SEVR will be evaluated on all patients belonging to the Arterial Hypertension Centers undergoing non-invasive arterial tonometry. The SEVR is calculated on the morphology of the central pressure wave as the ratio between the DPTI (diastolic pressure-time index), i.e. the area between the carotid pressure curve and the ventricular pressure curve during the diastolic phase, and the SPTI ( systolic pressure-time index), i.e. the area under the carotid pressure curve during the systolic phase. The SEVR will be correlated with the anthropometric and pathology variables which will be collected in an appropriate database.

Conditions

Hypertension

Keywords

Myocardial ischemia; Buckberg index

Outcome Measures

Primary Outcomes (1)

• Buckberg index

  Assessment of subendocardial viability ratio (SEVR)

  At recruitment, at 1 year, 2 years, 3 years and 4 years of follow-up

Interventions

Arterial tonometry DIAGNOSTIC_TEST

Arterial transcutaneous tonometry

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hypertensive patients

You may qualify if:

• Hypertension

You may not qualify if:

• Atrial fibrillation

Sponsors & Collaborators

• Istituto Auxologico Italiano: lead

Study Sites (5)

Centro di Prevenzione e Cura dell'Ipertensione Arteriosa "Alessandro Filippi"

Mascalucia, Catania, Italy

RECRUITING

Unità Operativa Semplice Dipartimentale Ipertensione Arteriosa "Anna Maria Pirrelli", Università degli Studi di Bari "Aldo Moro". Policlinico Consorziale di Bari

Bari, Italy

RECRUITING

Istituto Auxologico Italiano IRCCS

Milan, 20145, Italy

RECRUITING

Medicina II Cardiovascolare, AUSL-IRCCS di Reggio Emilia

Reggio Emilia, Italy

RECRUITING

Dipartimento di Scienze Mediche, Chirurgiche e della Salute, Università degli studi di Trieste

Trieste, Italy

RECRUITING

MeSH Terms

Conditions

Hypertension; Myocardial Ischemia

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Heart Diseases

Central Study Contacts

Paolo Salvi, MD

CONTACT

+390261911; p.salvi@auxologico.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2024
• First Posted: March 13, 2024
• Study Start: October 1, 2022
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 3, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

IT (5)