Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients

NCT06307717 | Completed

• 1 other identifier: PLAGH-DA-002
• Study Type: observational
• Target: 8,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.

Conditions

Cohort Studies

Keywords

Anxiety; Depression; Aged; Surgery; Volatile anaesthetics

Outcome Measures

Primary Outcomes (1)

• Depression

  Primary outcomes were depression Patient Health Questionnaire 9 (PHQ-9).The PHQ-9 is a nine-item questionnaire for screening on the presence of depressive symptoms and monitoring depression severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-seven. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe level of depression. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of depression. The higher the score, the worse the situation. The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms.

  Depression within 7 days of surgery

Secondary Outcomes (1)

• Anxiety

  Anxiety within 7 days of surgery

Study Arms (2)

volatile anaesthetic (sevoflurane, isoflurane, desflurane）

Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.

Drug: volatile anaesthetic (sevoflurane, isoflurane, desflurane)

control

Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.

Interventions

volatile anaesthetic (sevoflurane, isoflurane, desflurane) DRUG

Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.

Also known as: The blank group was without the use of any inhalation anesthetics

volatile anaesthetic (sevoflurane, isoflurane, desflurane）

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly patients (aged ≥ 65 years) who completed the anxiety and depression assessment on the seventh day after the elective noncardiac, non-neurosurgical surgery were included in this study.

You may qualify if:

• Geriatric surgical patients ≥65 years old Non-selective cardiac surgery Non-neurosurgical

You may not qualify if:

• underwent reoperation within 7 days
• ASA classification of Ⅳ or above
• history of serious mental illness or long-term use of psychotropic drugs
• patients either died or were transferred to the intensive care unit within 7 days of the surgery
• subjects with missing covariate data

Sponsors & Collaborators

• Chinese PLA General Hospital: lead
• Beijing Tsinghua Changgeng Hospital: collaborator
• Peking University First Hospital: collaborator
• The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School: collaborator
• Xiangya Hospital of Central South University: collaborator
• Beijing Anzhen Hospital: collaborator
• Central South University: collaborator
• Peking University People's Hospital: collaborator
• Zhejiang University: collaborator
• Fudan University: collaborator
• Sun Yat-sen University: collaborator
• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology: collaborator
• China-Japan Friendship Hospital: collaborator
• The Affiliated Hospital Of Guizhou Medical University: collaborator
• First Affiliated Hospital of Xinjiang Medical University: collaborator
• First Affiliated Hospital of Guangxi Medical University: collaborator
• Taihe Hospital: collaborator

Study Sites (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, China

Location

MeSH Terms

Conditions

Anxiety Disorders; Depression

Interventions

Sevoflurane; Isoflurane; Desflurane

Condition Hierarchy (Ancestors)

Mental Disorders; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Methyl Ethers; Ethers; Organic Chemicals; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Hydrocarbons; Ethyl Ethers

Study Officials

• WEIDONG MI, PhD

  Chinese PLA General Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director (Cheif expert of National key research and development program of China 2018YFC2001900)

Study Record Dates

• First Submitted: March 6, 2024
• First Posted: March 13, 2024
• Study Start: April 1, 2020
• Primary Completion: October 31, 2021
• Study Completion: April 30, 2022
• Last Updated: April 10, 2024

Record last verified: 2024-04

Locations

CN (1)