Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement

NCT06302296 | Recruiting

• 1 other identifier: Hama University/
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.

Conditions

Tooth Mobility; Injectable Platelet-rich Fibrin

Outcome Measures

Primary Outcomes (1)

• Leveling and alignment maxillary incisors

  \- Alginate impressions were taken at insertion of the first archwire (0.014-in nickel-titanium) maxillary incisors Leveling and alignment. Leveling and alignment were achieved through the following sequence of archwires: 0.014-in nickel-titanium (NiTi), 0.016 × 0.022-in NiTi, 0.017 × 0.025-in NiTi, 0.019 × 0.025-in stainless steel (SS)(3).

  One month ,two month,six month

Study Arms (2)

injectable form of PRF

EXPERIMENTAL

A group of patients in which participants will be undergo to orthodontic treatment will be received a 0.9 ml injection of PRF after 1st premolar extraction.

Device: injectable form of PRF

traditional orthodontic treatment

EXPERIMENTAL

A group of patients in which participants will be undergo to traditional orthodontic treatment will be received a Placebo injection after 1st premolar extraction.

Behavioral: Placebo injection

Interventions

injectable form of PRF DEVICE

A group of patients in which participants will be undergo to orthodontic treatment will be received a 0.9 ml injection of PRF after 1st premolar extraction.

injectable form of PRF

Placebo injection BEHAVIORAL

A group of patients in which participants will be undergo to traditional orthodontic treatment will be received a Placebo injection after 1st premolar extraction.

traditional orthodontic treatment

Eligibility Criteria

• Age: 18 Years - 26 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.
• Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.
• All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.
• The patient has good oral health.

You may not qualify if:

• The presence of any systemic disease that affects orthodontic dental movement.
• Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).
• The patient has undergone previous orthodontic treatment.
• The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).
• The patient has poor oral health.
• Commitment to periodic follow-up appointments.

Sponsors & Collaborators

• Hama University: lead

Study Sites (1)

Fadi Jnaid

Hama, Syria

RECRUITING

MeSH Terms

Conditions

Tooth Mobility

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Eisa Salami, MSc student

  Hama University

  PRINCIPAL INVESTIGATOR

• Rabab Alsabbagh, Professor

  Hama University

  STUDY CHAIR

Central Study Contacts

FADI JNAID, Associate Professor

CONTACT

988499015; Drfadijnaid@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Syria-Hama University

Study Record Dates

• First Submitted: March 4, 2024
• First Posted: March 8, 2024
• Study Start: December 20, 2025
• Primary Completion (Estimated): May 15, 2026
• Study Completion (Estimated): July 15, 2026
• Last Updated: September 15, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

SY (1)