Design of a Predictive Score for Contamination of Pediatric Blood Cultures

NCT06300736 | Active Not Recruiting

• 1 other identifier: 2023PI247
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The contamination rate for blood cultures is high in pediatrics, due to different sampling techniques and the difficulty of sampling small-weight children, thus favoring contamination of the devices at the time of sampling. It is also more difficult to distinguish contamination from true bacteremia in children at an early stage, notably due to the limited number of vials that can be taken at any one time. On a daily basis, clinicians are faced with the choice of whether or not to initiate probabilistic antibiotic therapy when faced with the result of a positive blood culture, particularly when identification is not yet available, but only direct examination. Contamination has major consequences for patient management. Studies in adults have shown that contamination increases hospital length of stay by 4 to 5 days, laboratory costs by +20% and recourse to intravenous antibiotic therapy by +39%. In children, studies came to the same conclusion, with greater prescription of antibiotics, particularly intravenous antibiotics, in patients with contaminated blood cultures than in patients with sterile blood cultures. It also showed that 26% of patients with contaminated blood cultures were initially hospitalized because of the positivity of this test. The aim of this research is to determine the factors associated with contamination, in order to create a predictive score that would help clinicians in their decision-making when receiving the blood culture result as "positive".

Conditions

Bacteremia

Keywords

Blood culture contamination; Predictive score

Outcome Measures

Primary Outcomes (1)

• Blood culture diagnosis

  Contamination or bacteriemia

  2 years

Secondary Outcomes (1)

• Score performance

  2 years

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Immunocompetent children hospitalized in a tertiary children hospital with blood culture

You may qualify if:

• Having a blood culture in children's hospital in Nancy
• Under 18 years old
• in emergency department, medical department, intensive care unit or surgical department

You may not qualify if:

• immunodepression
• post mortem blood culture
• blood culture in onco-haematology department

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

CHRU Nancy

Nancy, 54000, France

Location

MeSH Terms

Conditions

Bacteremia

Condition Hierarchy (Ancestors)

Bacterial Infections; Bacterial Infections and Mycoses; Infections; Sepsis; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Nathan GIROUX, MD

  Central Hospital, Nancy, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: March 3, 2024
• First Posted: March 8, 2024
• Study Start: January 1, 2022
• Primary Completion: October 1, 2024
• Study Completion: October 1, 2024
• Last Updated: March 8, 2024

Record last verified: 2024-03

Locations

FR (1)